SCHEMBL17115381

SCHEMBL17115381

CCCCC(CC)Cc1ccc2c(c1)c1ccccc1n2-c1ccc2oc3ccc(-c4ccc5oc6ccc(-n7c8ccccc8c8cc(C#N)ccc87)cc6c5c4)cc3c2c1

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 1/20 0.33
HPGD P15428 1/20 0.31
MAPK1 P28482 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
RORC P51449 2/20 0.30
ICMT O60725 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17115369 0.97 PTGER4 (0.32) PTGER4
SCHEMBL18707022 0.97 HPGD (0.33) PTGER4HPGDMAPK1SMN1; SMN2RORC
SCHEMBL17115482 0.95 HPGD (0.33) PTGER4HPGDMAPK1SMN1; SMN2RORC
SCHEMBL17115477 0.95 HPGD (0.33) PTGER4HPGDMAPK1SMN1; SMN2RORC
SCHEMBL17115372 0.94 PTGER4 (0.32) PTGER4HPGDMAPK1SMN1; SMN2
SCHEMBL17115461 0.86
SCHEMBL17115382 0.85 TSHR (0.42) PTGER4RORCICMT
SCHEMBL18707130 0.85 PGR (0.32) RORCICMT
SCHEMBL17115464 0.85 RORC (0.32) PTGER4RORC
SCHEMBL20116773 0.84 PGR (0.35) MAPK1RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3119770-B1 NEW DIBENZOFURANS AND DIBENZOTHIOPHENES IDEMITSU KOSAN CO (JP) 2018-05-02 EP disclosed
US-20170098781-A1 NEW DIBENZOFURANS AND DIBENZOTHIOPHENES IDEMITSU KOSAN CO., LTD. (JP) 2017-04-06 US disclosed
US-20170098781-A1 NEW DIBENZOFURANS AND DIBENZOTHIOPHENES IDEMITSU KOSAN CO., LTD. (JP) 2017-04-06 US disclosed
WO-2015140073-A1 NEW DIBENZOFURANS AND DIBENZOTHIOPHENES IDEMITSU KOSAN CO., LTD. (JP) 2015-09-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170098781-A1 NEW DIBENZOFURANS AND DIBENZOTHIOPHENES DBF4, DDT, SLC43A3 PTGER4 1060/4885HPGD 1982/4885MAPK1 1132/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.