Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.57 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.57 |
| ▸ | CCR3 | P51677 | 1/20 | 0.54 |
| ▸ | KDM5A | P29375 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | STS | P08842 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12853559 | 0.88 | USP30 (0.58) | ALDH1A1TSHRMAPTMEN1KMT2A | |
| SCHEMBL3124262 | 0.87 | USP30 (0.62) | ALDH1A1TSHRLMNAMAPTMEN1 | |
| SCHEMBL2957238 | 0.87 | USP30 (0.54) | ALDH1A1TSHRLMNAMAPTHTT | |
| SCHEMBL28457523 | 0.86 | ALDH1A1 (0.70) | ALDH1A1LMNAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL27633457 | 0.85 | KMT2A (0.61) | ALDH1A1MEN1KMT2AUSP30CCR3 | |
| SCHEMBL18050965 | 0.85 | USP30 (0.58) | ALDH1A1TSHRMAPTMEN1KMT2A | |
| SCHEMBL2962791 | 0.85 | ALDH1A1 (0.57) | ALDH1A1TSHRLMNAMAPTNPSR1 | |
| SCHEMBL4574282 | 0.85 | USP30 (0.60) | ALDH1A1TSHRSMN1; SMN2MEN1KMT2A | |
| SCHEMBL13199301 | 0.85 | KDM4E (0.68) | LMNANPSR1MEN1KMT2AUSP30 | |
| SCHEMBL14655033 | 0.84 | MEN1 (0.63) | ALDH1A1MEN1KMT2APOLBSTS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344471-B1 | 7-PIPERIDINOALKYL-3,4-DIHYDROQUINOLONE DERIVATIVE | TAISHO PHARMACEUTICAL CO LTD (JP) | 2013-07-24 | — | — | EP | disclosed |
| US-8461182-B2 | 7-piperidinoalkyl-3, 4-Dihydroquinolone derivative | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2013-06-11 | — | — | US | disclosed |
| US-20110178304-A1 | 7-PIPERIDINOALKYL-3, 4-DIHYDROQUINOLONE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2011-07-21 | — | — | US | disclosed |
| EP-2344471-A1 | 7-PIPERIDINOALKYL-3,4-DIHYDROQUINOLONE DERIVATIVE | Taisho Pharmaceutical Co., Ltd. (JP) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010038901-A1 | 7-PIPERIDINOALKYL-3,4-DIHYDROQUINOLONE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2010-04-08 | — | — | WO | disclosed |
| US-20100081825-A1 | 1-NAPHTHYL ALKYLPIPERIDINE DERIVATIVE | TAISHO PHARMACEUTICAL CO LTD (JP) | 2010-04-01 | — | — | US | disclosed |
| EP-2098509-A1 | 1-NAPHTHYL ALKYLPIPERIDINE DERIVATIVE | Taisho Pharmaceutical Co. Ltd. (JP) | 2009-09-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081825-A1 | 1-NAPHTHYL ALKYLPIPERIDINE DERIVATIVE | MCHR1, MCHR2, MC5R | ALDH1A1 2065/4885TSHR 35/4885LMNA 2398/4885 |
| US-20110178304-A1 | 7-PIPERIDINOALKYL-3, 4-DIHYDROQUINOLONE DERIVATIVE | MCHR1, MCHR2, GPR119 | ALDH1A1 1137/4885TSHR 126/4885LMNA 3909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.