Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.60 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.57 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.57 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1711950 | 0.85 | ALDH1A1 (0.69) | USP30ALDH1A1TSHRMCHR1MEN1 | |
| SCHEMBL8212410 | 0.82 | CARM1 (0.57) | USP30ALDH1A1MCHR1EPHX1GPR119 | |
| SCHEMBL29136109 | 0.82 | USP30 (0.70) | USP30ALDH1A1TSHRMCHR1HDAC4 | |
| SCHEMBL27633457 | 0.81 | KMT2A (0.61) | USP30ALDH1A1HDAC4MEN1KMT2A | |
| SCHEMBL12853559 | 0.81 | USP30 (0.58) | USP30ALDH1A1TSHRHDAC4EPHX1 | |
| SCHEMBL14655065 | 0.81 | HSD11B1 (0.63) | TAS1R3TAS1R1TAS1R2MEN1KMT2A | |
| SCHEMBL3124262 | 0.81 | USP30 (0.62) | USP30ALDH1A1TSHRHDAC4EPHX1 | |
| SCHEMBL2957238 | 0.81 | USP30 (0.54) | USP30ALDH1A1TSHRHDAC4EPHX1 | |
| SCHEMBL2960402 | 0.81 | MAPT (0.53) | USP30ALDH1A1TSHRHPGDRAB9A | |
| SCHEMBL2472926 | 0.80 | TAS1R3 (0.67) | TAS1R3TAS1R1TAS1R2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008065500-A2 | HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-06-05 | — | — | WO | disclosed |