Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLI1 | P08151 | 2/20 | 0.64 |
| ▸ | RELA | Q04206 | 1/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.58 |
| ▸ | CES2 | O00748 | 1/20 | 0.58 |
| ▸ | TOP2A | P11388 | 1/20 | 0.58 |
| ▸ | CES1 | P23141 | 1/20 | 0.58 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.55 |
| ▸ | PTGES | O14684 | 2/20 | 0.53 |
| ▸ | ALB | P02768 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | NT5E | P21589 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.46 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17124237 | 0.89 | GLI1 (0.73) | GLI1RELAPTPN1CES2TOP2A | |
| SCHEMBL2845856 | 0.89 | GLI1 (0.73) | GLI1RELAPTPN1CES2TOP2A | |
| SCHEMBL15713944 | 0.86 | GLI1 (0.85) | GLI1RELAPTPN1GPBAR1ALB | |
| SCHEMBL14086956 | 0.84 | PTPN1 (0.80) | GLI1RELAPTPN1CES2TOP2A | |
| SCHEMBL17124248 | 0.83 | PTGES (0.52) | GLI1RELAPTPN1CES2TOP2A | |
| Alphitolic Acid SCHEMBL1954405 | 0.79 | GLI1 (1.00) | GLI1RELAPTPN1CES2CES1 | |
| SCHEMBL15713945 | 0.78 | RELA (0.81) | GLI1RELAPTPN1TOP2AGPBAR1 | |
| SCHEMBL15713941 | 0.78 | RELA (0.81) | GLI1RELAPTPN1TOP2AGPBAR1 | |
| SCHEMBL17124257 | 0.76 | PTPN1 (0.76) | GLI1RELAPTPN1CES2TOP2A | |
| SCHEMBL17124273 | 0.75 | PTPN1 (0.72) | GLI1RELAPTPN1CES2TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150272922-A1 | Compounds for Reducing Glucocorticoids, and Methods of Treatment Thereof | BIONICHE ANIMAL HEALTH USA, INC. | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150272922-A1 | Compounds for Reducing Glucocorticoids, and Methods of Treatment Thereof | NR3C1, NR5A1, NR3C2 | GLI1 4165/4885RELA 437/4885PTPN1 855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.