Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 9/20 | 0.72 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.65 |
| ▸ | CCR6 | P51684 | 1/20 | 0.65 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.65 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.65 |
| ▸ | CASP3 | P42574 | 5/20 | 0.64 |
| ▸ | TERT | O14746 | 3/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.63 |
| ▸ | CASP1 | P29466 | 1/20 | 0.63 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17130126 | 0.94 | HSP90AA1 (0.74) | NR4A1HSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL26205000 | 0.92 | NR4A1 (0.75) | NR4A1HSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL26204983 | 0.92 | NR4A1 (0.85) | NR4A1HSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL26205001 | 0.90 | NR4A1 (0.74) | NR4A1HSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL17124753 | 0.90 | CASP3 (0.73) | NR4A1HSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL17124763 | 0.89 | NR4A1 (0.85) | NR4A1HSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL17124762 | 0.88 | CASP3 (0.77) | NR4A1HSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL17124746 | 0.87 | NR4A1 (0.72) | NR4A1HSP90AA1CCR6PAX8TLR9 | |
| SCHEMBL26205004 | 0.87 | NR4A1 (0.72) | NR4A1CASP3TERTPTPN1CASP1 | |
| SCHEMBL26204982 | 0.87 | NR4A1 (0.71) | NR4A1HSP90AA1CCR6PAX8TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180194709-A1 | COMPOUNDS FOR THE TREATMENT OF OBESITY AND METHODS OF USE THEREOF | THE CHILDREN'S MEDICAL CENTER CORPORATION | 2018-07-12 | — | — | US | disclosed |
| US-20150274634-A1 | COMPOUNDS FOR THE TREATMENT OF OBESITY AND METHODS OF USE THEREOF | THE CHILDREN'S MEDICAL CENTER CORPORATION | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180194709-A1 | COMPOUNDS FOR THE TREATMENT OF OBESITY AND METHODS OF USE THEREOF | GPR119, FABP4, ADIPOR1 | NR4A1 2631/4885HSP90AA1 2473/4885CCR6 674/4885 |
| US-20150274634-A1 | COMPOUNDS FOR THE TREATMENT OF OBESITY AND METHODS OF USE THEREOF | GPR119, FABP4, ADIPOR1 | NR4A1 2631/4885HSP90AA1 2473/4885CCR6 674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.