Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14541793 | 0.77 | XDH (0.56) | XDHAPPSLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL163366 | 0.76 | XDH (0.52) | XDHAPPLOXL2SLC6A2SLC6A4 | |
| SCHEMBL171266 | 0.76 | XDH (0.44) | XDHAPPKMOGAALMNA | |
| SCHEMBL15022887 | 0.75 | XDH (0.44) | XDHAPPLOXL2KMOGAA | |
| SCHEMBL174941 | 0.75 | DGAT1 (0.46) | LOXL2LOXL3MEN1KMT2AERCC5 | |
| Hydrochloric Acid SCHEMBL158931 | 0.73 | XDH (0.55) | XDHAPPLOXL2SLC6A2SLC6A4 | |
| SCHEMBL162946 | 0.73 | XDH (0.46) | XDHAPPGAALMNAMEN1 | |
| SCHEMBL15022047 | 0.72 | XDH (0.45) | XDHAPPLOXL2KMOGAA | |
| SCHEMBL163650 | 0.72 | XDH (0.45) | XDHAPPSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12503663 | 0.71 | XDH (0.47) | XDHAPPGAALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |