SCHEMBL1712974

SCHEMBL1712974

C#CC(CCCC(=O)O)C(=O)O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.47
CYP2D6 P10635 2/20 0.47
MAPT P10636 2/20 0.47
NFKB1 P19838 2/20 0.47
CYP1A2 P05177 2/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
HSD17B10 Q99714 1/20 0.43
SLC22A6 Q4U2R8 1/20 0.42
GRM8 O00222 1/20 0.41
GRM6 O15303 1/20 0.41
GRIN2D O15399 1/20 0.41
GRIN3B O60391 1/20 0.41
GSR P00390 1/20 0.41
GRIK1 P39086 1/20 0.41
GRM5 P41594 1/20 0.41
GRIA1 P42261 1/20 0.41
GRIA2 P42262 1/20 0.41
GRIA3 P42263 1/20 0.41
SLC1A3 P43003 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1712781 0.92 CYP2D6 (0.50) LMNACYP2D6MAPTNFKB1CYP1A2
SCHEMBL2261654 0.92 CYP2D6 (0.50) LMNACYP2D6MAPTNFKB1CYP1A2
SCHEMBL16836648 0.86 CYP2D6 (0.56) LMNACYP2D6MAPTNFKB1CYP1A2
SCHEMBL25173898 0.78 LMNA (0.42) LMNANFKB1CYP1A2SLC22A6GRM8
SCHEMBL23829652 0.77 GPR84 (0.50) MAPTGRIK1SLC1A2SLC1A1GRIK2
SCHEMBL2235480 0.76 LMNA (0.48) LMNACYP2D6MAPTNFKB1CYP1A2
SCHEMBL7738368 0.76 LMNA (0.48) LMNACYP2D6MAPTNFKB1CYP1A2
SCHEMBL1712183 0.75 FOLH1 (0.39) LMNANFKB1CYP1A2HSD17B10SLC22A6
SCHEMBL379236 0.74 LMNA (0.47) LMNACYP2D6MAPTNFKB1CYP1A2
SCHEMBL4301199 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2344568-B1 ACETYLENIC POLYAMIDE NEXAM CHEMICAL AB (SE) 2017-12-20 EP claimed
US-8492507-B2 Acetylenic polyamide NEXAM CHEMICAL AB (SE) 2013-07-23 US claimed
CN-102159622-A Acetylenic polyamide NEXAM CHEMICAL AB 2011-08-17 CN claimed
US-20110190469-A1 ACETYLENIC POLYAMIDE NEXAM CHEMICAL AB (SE) 2011-08-04 US claimed
EP-2344568-A1 ACETYLENIC POLYAMIDE Nexam Chemical AB (SE) 2011-07-20 EP claimed
WO-2010036170-A1 ACETYLENIC POLYAMIDE NEXAM CHEMICAL AB (SE) 2010-04-01 WO claimed
EP-2344568-B1 ACETYLENIC POLYAMIDE NEXAM CHEMICAL AB (SE) 2017-12-20 EP disclosed
US-8492507-B2 Acetylenic polyamide NEXAM CHEMICAL AB (SE) 2013-07-23 US disclosed
CN-102159622-A Acetylenic polyamide NEXAM CHEMICAL AB 2011-08-17 CN disclosed
US-20110190469-A1 ACETYLENIC POLYAMIDE NEXAM CHEMICAL AB (SE) 2011-08-04 US disclosed
EP-2344568-A1 ACETYLENIC POLYAMIDE Nexam Chemical AB (SE) 2011-07-20 EP disclosed
WO-2010036175-A1 MOULDED ARTICLE OBTAINED FROM ACETYLENIC POLYAMIDE NEXAM CHEMICALS (SE) 2010-04-01 WO disclosed
WO-2010036170-A1 ACETYLENIC POLYAMIDE NEXAM CHEMICAL AB (SE) 2010-04-01 WO disclosed