Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.64 |
| ▸ | MMP10 | P09238 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.55 |
| ▸ | MMP8 | P22894 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | DDT | P30046 | 3/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17132813 | 0.95 | MMP13 (0.56) | MMP13MMP10MMP9MMP8KDM4E | |
| SCHEMBL17132800 | 0.90 | MMP13 (0.69) | MMP13MMP10MMP9MMP8KDM4E | |
| SCHEMBL17132785 | 0.86 | MMP13 (0.66) | MMP13MMP10MMP9MMP8KDM4E | |
| SCHEMBL17132750 | 0.86 | MMP13 (0.72) | MMP13MMP10MMP9MMP8KDM4E | |
| SCHEMBL17132815 | 0.86 | MMP13 (0.73) | MMP13MMP10MMP9MMP8KDM4E | |
| SCHEMBL17132809 | 0.86 | MMP13 (0.76) | MMP13MMP10MMP9MMP8SMO | |
| SCHEMBL17132756 | 0.86 | MMP13 (0.79) | MMP13MMP10MMP9MMP8KDM4E | |
| SCHEMBL17132791 | 0.85 | MMP13 (0.60) | MMP13MMP10MMP9MMP8ALDH1A1 | |
| SCHEMBL17132781 | 0.83 | MMP13 (0.77) | MMP13MMP10MMP9MMP8KDM4E | |
| SCHEMBL17132810 | 0.82 | MMP13 (0.70) | MMP13MMP10MMP9MMP8SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505743-B2 | Matrix metalloproteinase inhibitors and methods for the treatment of pain and other diseases | AQUILUS PHARMACEUTICALS INC (US) | 2016-11-29 | — | — | US | disclosed |
| US-20150274702-A1 | MATRIX METALLOPROTEINASE INHIBITORS AND METHODS FOR THE TREATMENT OF PAIN AND OTHER DISEASES | SUCHOLEIKI IRVING (US) | 2015-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274702-A1 | MATRIX METALLOPROTEINASE INHIBITORS AND METHODS FOR THE TREATMENT OF PAIN AND OTHER DISEASES | MMP13, MMP3, MMP9 | MMP13 1/4885MMP10 8/4885MMP9 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.