Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ANPEP | P15144 | 2/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.42 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1752333 | 0.98 | ANPEP (0.41) | MEN1KMT2AANPEPERAP2ERAP1 | |
| SCHEMBL1619040 | 0.98 | ANPEP (0.41) | MEN1KMT2AANPEPERAP2ERAP1 | |
| SCHEMBL1674470 | 0.81 | MEN1 (0.55) | MEN1KMT2AANPEPERAP2TSHR | |
| SCHEMBL1619039 | 0.81 | ANPEP (0.38) | ANPEPERAP2ERAP1TSHRCYP2D6 | |
| SCHEMBL8558133 | 0.79 | USP2 (0.47) | MEN1KMT2AANPEPERAP2ERAP1 | |
| SCHEMBL7360096 | 0.79 | ANPEP (0.37) | ANPEPERAP2ERAP1TSHRCYP2D6 | |
| SCHEMBL8558131 | 0.79 | USP2 (0.47) | MEN1KMT2AANPEPERAP2ERAP1 | |
| SCHEMBL8553536 | 0.77 | MEN1 (0.46) | MEN1KMT2AANPEPERAP2TSHR | |
| SCHEMBL18205131 | 0.77 | MEN1 (0.50) | MEN1KMT2AANPEPERAP2CYP2D6 | |
| SCHEMBL6783279 | 0.77 | MEN1 (0.50) | MEN1KMT2AANPEPERAP2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768966-B1 | COUMPOUNDS AND METHODS FOR INHIBITING THE INTERACTION OF BCL PROTEINS WITH BINDING PARTNERS | INFINITY DISCOVERY INC (US) | 2012-03-07 | — | — | EP | disclosed |
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |