Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.88 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.55 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.50 |
| ▸ | TET3 | O43151 | 2/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.50 |
| ▸ | KDM4A | O75164 | 2/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.48 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL7574683 | 1.00 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2TET2TET3SLC22A6 | |
| Malic Acid SCHEMBL10492401 | 1.00 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2TET2TET3SLC22A6 | |
| Malic Acid SCHEMBL7568999 | 1.00 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2TET2TET3SLC22A6 | |
| Malic Acid SCHEMBL4269585 | 1.00 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2TET2TET3SLC22A6 | |
| Malic Acid SCHEMBL13570956 | 1.00 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2TET2TET3SLC22A6 | |
| Malic Acid SCHEMBL10884230 | 1.00 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2TET2TET3SLC22A6 | |
| Malic Acid SCHEMBL7573228 | 1.00 | SMN1; SMN2 (0.88) | SMN1; SMN2OR51E2TET2TET3SLC22A6 | |
| Malic Acid SCHEMBL123090 | 0.97 | SMN1; SMN2 (0.94) | SMN1; SMN2OR51E2TET2TET3SLC22A6 | |
| Malic Acid SCHEMBL28831630 | 0.97 | SMN1; SMN2 (0.94) | SMN1; SMN2OR51E2TET2TET3SLC22A6 | |
| Malic Acid SCHEMBL3408017 | 0.97 | SMN1; SMN2 (0.94) | SMN1; SMN2OR51E2TET2TET3SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026098867-A1 | OXIDATIVE HAIR BRIGHTENING BY MEANS OF PERSULFATE, DICARBOXYLIC ACID, AND CITRULLINE | HENKEL AG & CO. KGAA (DE) | 2026-05-15 | — | — | WO | disclosed |
| EP-4630123-A1 | MULTI-COMPONENT PACKAGING UNIT COMPRISING A FIRST PREPARATION (A) HAVING PEROXODISULPHATE, DI- OR TRICARBOXYLIC ACID AND AMINO ACID AND A SECOND PREPARATION (B) HAVING CARBAMIDE PEROXIDE | Henkel AG & Co. KGaA (DE) | 2025-10-15 | — | — | EP | disclosed |
| EP-4514306-A1 | OXIDATIVE HAIR-LIGHTENING AGENTS HAVING IMPROVED APPLICATION PROPERTIES FOR BLEACHING HAIR ROOTS | Henkel AG & Co. KGaA (DE) | 2025-03-05 | — | — | EP | disclosed |
| EP-4475813-A1 | OXIDATIVE HAIR TREATMENT AGENT WITH A CONTROLLED HEAT DEVELOPMENT BASED ON ENVIRONMENTALLY FRIENDLY CONTENTS | Henkel AG & Co. KGaA (DE) | 2024-12-18 | — | — | EP | disclosed |
| US-20240390245-A1 | OXIDATIVE HAIR TREATMENT AGENT WITH A CONTROLLED HEAT DEVELOPMENT BASED ON ENVIRONMENTALLY FRIENDLY CONTENTS | HENKEL AG & CO. KGAA (DE) | 2024-11-28 | — | — | US | disclosed |
| WO-2024120663-A1 | MULTI-COMPONENT PACKAGING UNIT COMPRISING A FIRST PREPARATION (A) HAVING PEROXODISULPHATE, DI- OR TRICARBOXYLIC ACID AND AMINO ACID AND A SECOND PREPARATION (B) HAVING CARBAMIDE PEROXIDE | HENKEL AG & CO. KGAA (DE) | 2024-06-13 | — | — | WO | disclosed |
| WO-2023208489-A1 | OXIDATIVE HAIR-LIGHTENING AGENTS HAVING IMPROVED APPLICATION PROPERTIES FOR BLEACHING HAIR ROOTS | HENKEL AG & CO. KGAA (DE) | 2023-11-02 | — | — | WO | disclosed |
| WO-2023208488-A1 | OXIDATIVE HAIR LIGHTENING PRODUCT WITH CONTROLLED SWELLING BEHAVIOR | HENKEL AG & CO. KGAA (DE) | 2023-11-02 | — | — | WO | disclosed |
| WO-2023151873-A1 | OXIDATIVE HAIR TREATMENT AGENT WITH A CONTROLLED HEAT DEVELOPMENT BASED ON ENVIRONMENTALLY FRIENDLY CONTENTS | HENKEL AG & CO. KGAA (DE) | 2023-08-17 | — | — | WO | disclosed |
| US-11661511-B2 | Production method of polyacetal resin composition | POLYPLASTICS CO., LTD. (JP) | 2023-05-30 | — | — | US | disclosed |
| US-20170340553-A1 | PASTE-LIKE BLEACHING AGENT AND METHOD FOR GENTLE OXIDATIVE HAIR LIGHTENING | HENKEL AG & CO. KGAA (DE) | 2017-11-30 | — | — | US | disclosed |
| US-9745400-B2 | Method for producing polyacetal copolymer | POLYPLASTICS CO., LTD. (JP) | 2017-08-29 | — | — | US | disclosed |
| US-9695265-B2 | Process for producing polyacetal copolymer | POLYPLASTICS CO., LTD. (JP) | 2017-07-04 | — | — | US | disclosed |
| US-9657136-B2 | Production method for polyacetal copolymer | POLYPLASTICS CO., LTD. (JP) | 2017-05-23 | — | — | US | disclosed |
| US-20170114176-A1 | METHOD FOR PRODUCING POLYACETAL COPOLYMER | POLYPLASTICS CO., LTD. (JP) | 2017-04-27 | — | — | US | disclosed |
| US-20170073451-A1 | PROCESS FOR PRODUCING POLYACETAL COPOLYMER | POLYPLASTICS CO., LTD. (JP) | 2017-03-16 | — | — | US | disclosed |
| EP-3109266-A1 | PROCESS FOR PRODUCING POLYACETAL COPOLYMER | Polyplastics Co., Ltd. (JP) | 2016-12-28 | — | — | EP | disclosed |
| EP-3109267-A1 | METHOD FOR PRODUCING POLYACETAL COPOLYMER | Polyplastics Co., Ltd. (JP) | 2016-12-28 | — | — | EP | disclosed |
| US-20160280852-A1 | PRODUCTION METHOD FOR POLYACETAL COPOLYMER | POLYPLASTICS CO., LTD. (JP) | 2016-09-29 | — | — | US | disclosed |
| EP-2927254-A1 | PRODUCTION METHOD FOR POLYACETAL COPOLYMER | Polyplastics Co., Ltd. (JP) | 2015-10-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240390245-A1 | OXIDATIVE HAIR TREATMENT AGENT WITH A CONTROLLED HEAT DEVELOPMENT BASED ON ENVIRONMENTALLY FRIENDLY CONTENTS | GPX4, TYR, GPX1 | SMN1; SMN2 4232/4885OR51E2 2122/4885TET2 175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.