Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.53 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.50 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28544959 | 0.85 | CYP11B1 (0.57) | CYP11B1CYP11B2HRH4HRH3TBXAS1 | |
| SCHEMBL14257669 | 0.84 | CYP1A2 (0.56) | CHRNA7CYP2A6CYP11B1CYP11B2HRH4 | |
| Picolamine SCHEMBL30046657 | 0.82 | — | — | |
| Picolamine SCHEMBL29394769 | 0.82 | — | — | |
| Picolamine SCHEMBL17850 | 0.82 | — | — | |
| SCHEMBL20961846 | 0.82 | LOXL2 (0.60) | LOXL2HRH3CYP3A4 | |
| SCHEMBL727185 | 0.82 | CYP1A2 (0.62) | CHRNA7CYP2A6CYP11B1CYP11B2HRH4 | |
| SCHEMBL9593116 | 0.81 | MEN1 (0.55) | CHRNA7CYP2A6CYP11B1CYP11B2HRH4 | |
| SCHEMBL171386 | 0.81 | LOXL2 (0.64) | LOXL2CYP11B1CYP11B2CYP3A4PRKCI | |
| Picolamine SCHEMBL11870934 | 0.80 | CHRNA7 (0.65) | CHRNA7CYP2A6LOXL2HRH1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426122-A1 | Methylene urea derivative as RAF kinasse inhibitors | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |