Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 5/20 | 0.64 |
| ▸ | CYP17A1 | P05093 | 6/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.50 |
| ▸ | PRKCI | P41743 | 1/20 | 0.49 |
| ▸ | PNMT | P11086 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LOX | P28300 | 1/20 | 0.42 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171163 | 0.85 | LOXL2 (0.80) | LOXL2CYP17A1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL20961846 | 0.85 | LOXL2 (0.60) | LOXL2CYP3A4PNMTENPP2PRMT6 | |
| SCHEMBL27736120 | 0.84 | LOXL2 (0.64) | LOXL2CYP3A4CYP19A1PNMTENPP2 | |
| SCHEMBL922725 | 0.83 | LOXL2 (0.67) | LOXL2CYP3A4PNMTENPP2PRMT6 | |
| SCHEMBL171355 | 0.81 | CHRNA7 (0.53) | LOXL2CYP11B1CYP11B2CYP3A4PRKCI | |
| SCHEMBL177850 | 0.80 | CYP11B1 (0.69) | LOXL2CYP17A1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL41000 | 0.80 | — | — | |
| SCHEMBL14257671 | 0.78 | CYP17A1 (0.54) | LOXL2CYP17A1CYP11B1CYP11B2CYP3A4 | |
| Hydrochloric Acid SCHEMBL17337033 | 0.78 | LOXL2 (0.94) | LOXL2CYP3A4LOXLOXL3 | |
| Hydrochloric Acid SCHEMBL2674696 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426122-A1 | Methylene urea derivative as RAF kinasse inhibitors | Merck Patent GmbH (DE) | 2012-03-07 | — | — | EP | disclosed |