Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 6/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14320404 | 0.92 | LMNA (0.52) | HTTMEN1KMT2AROCK2ROCK1 | |
| SCHEMBL14320319 | 0.85 | MEN1 (0.43) | MEN1KMT2AROCK2ROCK1L3MBTL1 | |
| SCHEMBL14320598 | 0.85 | SYK (0.47) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| SCHEMBL17135645 | 0.85 | HTT (0.40) | HTTMEN1KMT2AROCK2ALDH1A1 | |
| SCHEMBL15650370 | 0.84 | SYK (0.46) | HTTROCK2ROCK1ALDH1A1LMNA | |
| SCHEMBL14320613 | 0.84 | BTK (0.42) | MEN1KMT2AROCK2ROCK1L3MBTL1 | |
| SCHEMBL14320556 | 0.83 | JAK2 (0.44) | HTTROCK2ALDH1A1LMNAKIF11 | |
| SCHEMBL14320685 | 0.82 | ABCG2 (0.40) | HTTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL14320672 | 0.79 | ABCG2 (0.54) | MEN1KMT2AABCG2SYKPDE5A | |
| SCHEMBL17135656 | 0.79 | ROCK2 (0.51) | MEN1KMT2AROCK2ROCK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2699579-B1 | PYRAZOLO[4,3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS | ORIGENIS GMBH (DE) | 2015-10-07 | — | — | EP | claimed |