Depreotide

Depreotide

SCHEMBL17136142

CC(C)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](CCSCC(=O)NC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(N)=O)NC1=O.O=C(O)C(F)(F)F

nearest known ligand 0.76

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SSTR5 P35346 17/20 0.76
SSTR2 P30874 16/20 0.76
SSTR3 P32745 9/20 0.76
SSTR1 P30872 9/20 0.76
SSTR4 P31391 8/20 0.76
IL23R Q5VWK5 1/20 0.43
DRD2 P14416 4/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Depreotide SCHEMBL29399302 0.97 SSTR5 (0.79) SSTR5SSTR2SSTR3SSTR1SSTR4
Depreotide SCHEMBL456503 0.97 SSTR5 (0.79) SSTR5SSTR2SSTR3SSTR1SSTR4
Depreotide SCHEMBL29392879 0.85 SSTR5 (0.62) SSTR5SSTR2SSTR3SSTR1SSTR4
SCHEMBL24108700 0.81 SSTR5 (1.00) SSTR5SSTR2SSTR3SSTR1SSTR4
SCHEMBL22214904 0.81 SSTR5 (1.00) SSTR5SSTR2SSTR3SSTR1SSTR4
Vapreotide SCHEMBL5200070 0.71 SSTR2 (0.78) SSTR5SSTR2SSTR3SSTR1SSTR4
Seglitide SCHEMBL25456114 0.71 SSTR5 (0.56) SSTR5SSTR2SSTR3SSTR1SSTR4
Seglitide SCHEMBL151244 0.71 SSTR5 (0.56) SSTR5SSTR2SSTR3SSTR1SSTR4
Seglitide SCHEMBL29691513 0.71 SSTR5 (0.56) SSTR5SSTR2SSTR3SSTR1SSTR4
Seglitide SCHEMBL29392970 0.71 SSTR5 (0.56) SSTR5SSTR2SSTR3SSTR1SSTR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210106538-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF BIOMACROMOLECULE AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2021-04-15 US claimed
EP-3471778-A2 COMPOSITIONS AND METHODS FOR DELIVERY OF BIOMACROMOLECULE AGENTS The Regents of The University of Michigan (US) 2019-04-24 EP claimed
WO-2018156617-A2 COMPOSITIONS AND METHODS FOR DELIVERY OF POLYMER / BIOMACROMOLECULE CONJUGATES THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2018-08-30 WO claimed
WO-2017223085-A2 COMPOSITIONS AND METHODS FOR DELIVERY OF BIOMACROMOLECULE AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2017-12-28 WO claimed
US-12622922-B2 Compositions and methods for metal containing formulations capable of modulating immune response THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2026-05-12 US disclosed
US-20250375388-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF BIOMACROMOLECULE AGENTS UNIV MICHIGAN REGENTS (US) 2025-12-11 US disclosed
US-20250213474-A1 COMPOSITIONS AND METHODS FOR METAL CONTAINING FORMULATIONS CAPABLE OF MODULATING IMMUNE RESPONSE THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2025-07-03 US disclosed
US-12257352-B2 Compositions and methods for delivery of biomacromolecule agents THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2025-03-25 US disclosed
US-20240277751-A1 CRYSTALLINE POLYMORPHIC FORMS OF STING AGONISTS ASSOCIATED WITH METAL IONS CAPABLE OF MODULATING AN IMMUNE RESPONSE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-08-22 US disclosed
EP-4408480-A1 COMPOSITIONS AND METHODS FOR METAL CONTAINING FORMULATIONS CAPABLE OF MODULATING IMMUNE RESPONSE The Regents Of The University Of Michigan (US) 2024-08-07 EP disclosed
EP-4228657-A1 CRYSTALLINE POLYMORPHIC FORMS OF STING AGONISTS ASSOCIATED WITH METAL IONS CAPABLE OF MODULATING AN IMMUNE RESPONSE The Regents Of The University Of Michigan (US) 2023-08-23 EP disclosed
CN-116390764-A Crystalline polymorphic forms of STING agonist bound to metal ions capable of modulating immune responses 密歇根大学董事会 2023-07-04 CN disclosed
WO-2021119439-A1 COMPOSITIONS AND METHODS FOR SYSTEMIC DELIVERY OF BCL-2 AND BCL-XL ANTAGONISTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2021-06-17 WO disclosed
EP-3820534-A1 COMPOSITIONS AND METHODS FOR METAL CONTAINING FORMULATIONS CAPABLE OF MODULATING IMMUNE RESPONSE The Regents Of The University Of Michigan (US) 2021-05-19 EP disclosed
US-20210106538-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF BIOMACROMOLECULE AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2021-04-15 US disclosed
EP-3471778-A2 COMPOSITIONS AND METHODS FOR DELIVERY OF BIOMACROMOLECULE AGENTS The Regents of The University of Michigan (US) 2019-04-24 EP disclosed
WO-2018156617-A2 COMPOSITIONS AND METHODS FOR DELIVERY OF POLYMER / BIOMACROMOLECULE CONJUGATES THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2018-08-30 WO disclosed
WO-2017223085-A2 COMPOSITIONS AND METHODS FOR DELIVERY OF BIOMACROMOLECULE AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2017-12-28 WO disclosed
US-9427483-B2 Radioisotope trithiol complexes THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) 2016-08-30 US disclosed
US-20150283274-A1 RADIOISOTOPE TRITHIOL COMPLEXES THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) 2015-10-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250213474-A1 COMPOSITIONS AND METHODS FOR METAL CONTAINING FORMULATIONS CAPABLE OF MODULATING IMMUNE RESPONSE MYD88, STING1, TLR3 SSTR5 4568/4885SSTR2 4673/4885SSTR3 4576/4885
US-20150283274-A1 RADIOISOTOPE TRITHIOL COMPLEXES ICMT, QTRT1, QPCT SSTR5 83/4885SSTR2 118/4885SSTR3 37/4885
US-20240277751-A1 CRYSTALLINE POLYMORPHIC FORMS OF STING AGONISTS ASSOCIATED WITH METAL IONS CAPABLE OF MODULATING AN IMMUNE RESPONSE STING1, CGAS, IRF3 SSTR5 2981/4885SSTR2 2547/4885SSTR3 1233/4885
US-12622922-B2 Compositions and methods for metal containing formulations capable of modulating immune response STING1, CGAS, TLR3 SSTR5 3634/4885SSTR2 2182/4885SSTR3 2548/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.