SCHEMBL17138355

SCHEMBL17138355

C[Si](Br)(Br)C=Cc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.46
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
CHAT P28329 2/20 0.41
ALDH1A1 P00352 5/20 0.41
KDM4E B2RXH2 3/20 0.41
HPGD P15428 3/20 0.41
TRPA1 O75762 2/20 0.40
RELA Q04206 1/20 0.40
CYP11B1 P15538 1/20 0.40
CYP11B2 P19099 1/20 0.40
GLA P06280 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
GRM5 P41594 2/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
GRM4 Q14833 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17138354 1.00 MAOB (0.46) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL8674275 0.86 MAOB (0.46) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL17156493 0.86 MAOB (0.46) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL17138294 0.80 MAOB (0.50) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL5845622 0.80 MAOB (0.50) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL7649592 0.80 MAOB (0.50) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL373962 0.80 MAOB (0.50) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL17138292 0.80 MAOB (0.50) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL14946408 0.80 MAOB (0.50) MAOBMEN1KMT2ACHATALDH1A1
SCHEMBL23200492 0.78 MAOB (0.48) MAOBMEN1KMT2ACHATALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2930177-B1 PREPARATION OF SILAZANE COMPOUND SHINETSU CHEMICAL CO (JP) 2018-04-25 EP disclosed
US-9416147-B2 Preparation of silazane compound SHIN-ETSU CHEMICAL CO., LTD. (JP) 2016-08-16 US disclosed
EP-2930177-A1 Preparation of silazane compound Shin-Etsu Chemical Co., Ltd. (JP) 2015-10-14 EP disclosed
US-20150284414-A1 PREPARATION OF SILAZANE COMPOUND SHIN-ETSU CHEMICAL CO., LTD. (JP) 2015-10-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150284414-A1 PREPARATION OF SILAZANE COMPOUND SLTM, SKP2, BCAT2 MAOB 3996/4885MEN1 3548/4885KMT2A 236/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.