SCHEMBL17138294

SCHEMBL17138294

Br[Si](Br)(Br)C=Cc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.50
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
CYP11B1 P15538 1/20 0.43
CYP11B2 P19099 1/20 0.43
ALDH1A1 P00352 4/20 0.42
LMNA P02545 2/20 0.42
NFE2L2 Q16236 2/20 0.42
CYP19A1 P11511 2/20 0.42
MAOA P21397 2/20 0.42
TRPA1 O75762 2/20 0.42
ALOX5 P09917 1/20 0.42
MAPK1 P28482 1/20 0.42
KDM4E B2RXH2 2/20 0.41
HPGD P15428 2/20 0.41
HDAC3 O15379 1/20 0.41
TNKS O95271 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HCAR2 Q8TDS4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17138292 1.00 MAOB (0.50) MAOBMEN1KMT2ACYP11B1CYP11B2
SCHEMBL17156493 0.80 MAOB (0.46) MAOBMEN1KMT2ACYP11B1CYP11B2
SCHEMBL17138354 0.80 MAOB (0.46) MAOBMEN1KMT2ACYP11B1CYP11B2
SCHEMBL17138355 0.80 MAOB (0.46) MAOBMEN1KMT2ACYP11B1CYP11B2
SCHEMBL8674275 0.80 MAOB (0.46) MAOBMEN1KMT2ACYP11B1CYP11B2
SCHEMBL5845622 0.74 MAOB (0.50) MAOBMEN1KMT2ACYP11B1CYP11B2
SCHEMBL3162837 0.74 MAOB (0.50) MAOBMEN1KMT2ACYP11B1CYP11B2
SCHEMBL2045920 0.74 MAOB (0.50) MAOBMEN1KMT2ACYP11B1CYP11B2
SCHEMBL30018146 0.74 MAOB (0.50) MAOBMEN1KMT2ACYP11B1CYP11B2
SCHEMBL2045922 0.74 MAOB (0.50) MAOBMEN1KMT2ACYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2930177-B1 PREPARATION OF SILAZANE COMPOUND SHINETSU CHEMICAL CO (JP) 2018-04-25 EP disclosed
US-9416147-B2 Preparation of silazane compound SHIN-ETSU CHEMICAL CO., LTD. (JP) 2016-08-16 US disclosed
EP-2930177-A1 Preparation of silazane compound Shin-Etsu Chemical Co., Ltd. (JP) 2015-10-14 EP disclosed
US-20150284414-A1 PREPARATION OF SILAZANE COMPOUND SHIN-ETSU CHEMICAL CO., LTD. (JP) 2015-10-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150284414-A1 PREPARATION OF SILAZANE COMPOUND SLTM, SKP2, BCAT2 MAOB 3996/4885MEN1 3548/4885KMT2A 236/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.