SCHEMBL17138754

SCHEMBL17138754

O=C1NCCCN1C1CCC1

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CDA P32320 2/20 0.42
NPY5R Q15761 1/20 0.39
F10 P00742 2/20 0.38
NOS3 P29474 1/20 0.38
NOS1 P29475 1/20 0.38
F2 P00734 1/20 0.36
F9 P00740 1/20 0.36
PLAT P00750 1/20 0.36
KLKB1 P03952 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
MAPK1 P28482 1/20 0.34
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
HTR2C P28335 2/20 0.33
HTR2B P41595 2/20 0.33
MEN1 O00255 1/20 0.33
GAA P10253 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19271812 0.96 CDA (0.42) CDANPY5RF10NOS3NOS1
SCHEMBL11215508 0.94 CDA (0.44) CDANPY5RF10NOS3NOS1
SCHEMBL5827421 0.93 CDA (0.44) CDANPY5RF10NOS3NOS1
SCHEMBL17138583 0.89 KDM4E (0.39) CDANPY5RF10NOS3NOS1
SCHEMBL25307809 0.88 CDA (0.46) CDANOS3NOS1KDM4EALDH1A1
SCHEMBL1973236 0.88 HTR2C (0.45) CDANPY5RF10NOS3NOS1
SCHEMBL6082054 0.88 CDA (0.46) CDANOS3NOS1KDM4EALDH1A1
SCHEMBL10982543 0.88 CDA (0.46) CDANOS3NOS1KDM4EALDH1A1
SCHEMBL6531351 0.87 NOS1 (0.42) CDANPY5RF10NOS3NOS1
SCHEMBL6160028 0.86 CDA (0.40) CDANPY5RF10NOS3NOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240190837-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS SYCHRONICITY PHARMA INC (US) 2024-06-13 US disclosed
US-20220411399-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS SYCHRONICITY PHARMA INC (US) 2022-12-29 US disclosed
US-20220411399-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS SYCHRONICITY PHARMA INC (US) 2022-12-29 US disclosed
EP-3939971-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. (US) 2022-01-19 EP disclosed
EP-3939971-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. (US) 2022-01-19 EP disclosed
US-20210171495-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. 2021-06-10 US disclosed
US-20210171495-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. 2021-06-10 US disclosed
EP-3129366-B1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS SYNCHRONICITY PHARMA INC (US) 2021-06-09 EP disclosed
EP-3129366-B1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS SYNCHRONICITY PHARMA INC (US) 2021-06-09 EP disclosed
US-10759777-B2 Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators Synchronicity Pharma, Inc. (US) 2020-09-01 US disclosed
US-10759777-B2 Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators Synchronicity Pharma, Inc. (US) 2020-09-01 US disclosed
US-20190241540-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. 2019-08-08 US disclosed
US-20190241540-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. 2019-08-08 US disclosed
US-20180334446-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. 2018-11-22 US disclosed
US-10005759-B2 Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators RESET THERAPEUTICS, INC. (US) 2018-06-26 US disclosed
US-10005759-B2 Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators RESET THERAPEUTICS, INC. (US) 2018-06-26 US disclosed
WO-2015157182-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS RESET THERAPEUTICS, INC. (US) 2015-10-15 WO disclosed
US-20150284362-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. 2015-10-08 US disclosed
US-20150284362-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. 2015-10-08 US disclosed
US-20150284362-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS Synchronicity Pharma, Inc. 2015-10-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190241540-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS CRY1, CRY2, HCCS CDA 851/4885NPY5R 489/4885F10 2721/4885
US-20150284362-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS CRY1, CRY2, HCCS CDA 851/4885NPY5R 489/4885F10 2721/4885
US-20180334446-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS CRY1, CRY2, HCCS CDA 851/4885NPY5R 489/4885F10 2721/4885
US-20210171495-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS CRY1, CRY2, HCCS CDA 851/4885NPY5R 489/4885F10 2721/4885
US-10759777-B2 Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators CRY1, CRY2, HCCS CDA 851/4885NPY5R 489/4885F10 2721/4885
US-20220411399-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS CRY1, CRY2, HCCS CDA 851/4885NPY5R 489/4885F10 2721/4885
US-10005759-B2 Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators CRY1, CRY2, HCCS CDA 851/4885NPY5R 489/4885F10 2721/4885
US-20240190837-A1 CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS CRY1, CRY2, HCCS CDA 851/4885NPY5R 489/4885F10 2721/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.