Sugi Predict

Sugi Predict / Compounds / SCHEMBL1714034

SCHEMBL1714034

SCHEMBL1714034

Cc1ccc2c(N[C@H]3c4cccc(O)c4[C@H](C)C[C@]3(O)C(F)(F)F)cccc2n1

nearest known ligand 0.81

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 P04150 12/20 0.81
▸ PGR P06401 3/20 0.66
▸ AR P10275 2/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ POLB P06746 2/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ P2RX7 Q99572 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12893347 1.00 NR3C1 (0.81) NR3C1PGRARL3MBTL1POLB
SCHEMBL14422072 1.00 NR3C1 (0.81) NR3C1PGRARL3MBTL1POLB
SCHEMBL12893346 1.00 NR3C1 (0.81) NR3C1PGRARL3MBTL1POLB
SCHEMBL3749873 0.90 NR3C1 (1.00) NR3C1PGRARL3MBTL1POLB
SCHEMBL1261596 0.90 NR3C1 (1.00) NR3C1PGRARL3MBTL1POLB
SCHEMBL1261598 0.90 NR3C1 (1.00) NR3C1PGRARL3MBTL1POLB
SCHEMBL12893348 0.89 NR3C1 (0.82) NR3C1PGRARL3MBTL1POLB
SCHEMBL13080559 0.88 NR3C1 (0.64) NR3C1PGRAR
SCHEMBL13052202 0.88 NR3C1 (0.64) NR3C1PGRAR
SCHEMBL1713236 0.85 NR3C1 (0.78) NR3C1PGRARL3MBTL1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1994005-B9 TETRAHYDRONAPHTHALINE DERIVATIVES, METHODS FOR THE PRODUCTION AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS Bayer Pharma AG (DE) 2012-01-11 — — EP claimed
EP-1994005-B1 TETRAHYDRONAPHTHALINE DERIVATIVES, METHODS FOR THE PRODUCTION AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS BAYER SCHERING PHARMA AG (DE) 2011-07-20 — — EP claimed
US-7880042-B2 antiinflammatory agents; (5 alpha ,6 alpha ,8 beta )-2-fluoro-8-methyl-5-[(2-methylquinoline-5-yl)amino]-6-(trifluoromethyl)-5,6,7,8-tetrahydronaphthalene-1,6-diol; side effect reduction BAYER SCHERING PHARMA AG (DE) 2011-02-01 — — US disclosed
US-20100298311-A1 TETRAHYDRONAPHTHALENE DERIVATES, PROCESS FOR PREPARING THEM AND THEIR USE AS ANTIINFLAMMATORY AGENTS BERGER MARKUS 2010-11-25 — — US disclosed
US-20100298311-A1 TETRAHYDRONAPHTHALENE DERIVATES, PROCESS FOR PREPARING THEM AND THEIR USE AS ANTIINFLAMMATORY AGENTS BERGER MARKUS 2010-11-25 — — US disclosed
US-20070225290-A1 Tetrahydronaphthalene derivates, processes for preparing them and their use as antiinflammatory agents BAYER SCHERING PHARMA AG (DE) 2007-09-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070225290-A1 Tetrahydronaphthalene derivates, processes for preparing them and their use as antiinflammatory agents TNF, IL1B, DHPS NR3C1 234/4885PGR 2717/4885AR 2749/4885
US-20100298311-A1 TETRAHYDRONAPHTHALENE DERIVATES, PROCESS FOR PREPARING THEM AND THEIR USE AS ANTIINFLAMMATORY AGENTS TNF, IL1B, DHPS NR3C1 286/4885PGR 2807/4885AR 2826/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.