Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | S100A4 | P26447 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28205894 | 0.84 | ALDH1A1 (0.47) | LMNAALDH1A1GAAMAPTCYP3A4 | |
| SCHEMBL5369158 | 0.81 | KDM4E (0.49) | LMNAALDH1A1GAAMAPTCYP3A4 | |
| SCHEMBL4189659 | 0.81 | KDM4E (0.49) | LMNAALDH1A1GAAMAPTCYP3A4 | |
| SCHEMBL29365110 | 0.81 | KDM4E (0.49) | LMNAALDH1A1GAAMAPTCYP3A4 | |
| SCHEMBL8600372 | 0.81 | LMNA (0.48) | LMNAALDH1A1GAAMAPTCYP3A4 | |
| SCHEMBL27443458 | 0.80 | LMNA (0.44) | LMNAALDH1A1GAAMAPTCYP3A4 | |
| SCHEMBL7254199 | 0.80 | LMNA (0.54) | LMNAALDH1A1GAAMAPTCYP3A4 | |
| SCHEMBL27941270 | 0.79 | TLR8 (0.49) | LMNAALDH1A1GAAMAPTCYP3A4 | |
| SCHEMBL14952438 | 0.78 | BID (0.48) | LMNAALDH1A1GAAMAPTCYP3A4 | |
| SCHEMBL2566789 | 0.76 | BID (0.46) | LMNAALDH1A1GAAMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3126333-A1 | PQSR MODULATORS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2017-02-08 | — | — | EP | disclosed |
| WO-2015149821-A1 | PQSR MODULATORS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2015-10-08 | — | — | WO | disclosed |