Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA3 | P07451 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA6 | P23280 | 2/20 | 0.38 |
| ▸ | CA5A | P35218 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.38 |
| ▸ | EEF2K | O00418 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL312901 | 0.83 | CA9 (0.44) | CA2CA9ALDH1A1CYP3A4CA1 | |
| SCHEMBL576531 | 0.82 | CA2 (0.47) | CA2CA9ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL13707919 | 0.78 | MAPK1 (0.46) | CA2CA9ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL20690134 | 0.78 | CA2 (0.40) | CA2CA9CYP3A4MAPK1TDP1 | |
| SCHEMBL29259800 | 0.77 | NPC1 (0.46) | CA2CA9ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL27670058 | 0.77 | ALDH1A1 (0.45) | CA2CA9ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL6115151 | 0.75 | ALDH1A1 (0.52) | CA2CA9ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL28798399 | 0.75 | GAA (0.44) | CA2CA9ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL23611478 | 0.74 | ALDH1A1 (0.43) | CA2CA9ALDH1A1CYP3A4CA1 | |
| SCHEMBL17302747 | 0.74 | ALDH1A1 (0.43) | CA2CA9ALDH1A1CYP3A4CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034960-B2 | Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as cPLA2 inhibitors | PFIZER INC. (US) | 2011-10-11 | — | — | US | disclosed |
| US-8034960-B2 | Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as cPLA2 inhibitors | PFIZER INC. (US) | 2011-10-11 | — | — | US | disclosed |
| US-8034960-B2 | Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as cPLA2 inhibitors | PFIZER INC. (US) | 2011-10-11 | — | — | US | disclosed |
| EP-1778629-B1 | PROCESS FOR THE SYNTHESIS C-2, C-3 SUBSTITUTED N-ALKYLATED INDOLES USEFUL AS CPLA2 INHIBITORS | WYETH LLC (US) | 2011-07-20 | — | — | EP | disclosed |
| US-20110054189-A1 | Process For The Synthesis C-2, C-3 Substituted N-Alkylated Indoles Useful As CPLA2 Inhibitors | WYETH LLC | 2011-03-03 | — | — | US | disclosed |
| US-20110054189-A1 | Process For The Synthesis C-2, C-3 Substituted N-Alkylated Indoles Useful As CPLA2 Inhibitors | WYETH LLC | 2011-03-03 | — | — | US | disclosed |
| US-20110054189-A1 | Process For The Synthesis C-2, C-3 Substituted N-Alkylated Indoles Useful As CPLA2 Inhibitors | WYETH LLC | 2011-03-03 | — | — | US | disclosed |
| US-7842837-B2 | Process for the synthesis of C-2, C-3 substituted N-alkylated indoles useful as cPLA2 inhibitors | WYETH LLC (US) | 2010-11-30 | — | — | US | disclosed |
| US-7842837-B2 | Process for the synthesis of C-2, C-3 substituted N-alkylated indoles useful as cPLA2 inhibitors | WYETH LLC (US) | 2010-11-30 | — | — | US | disclosed |
| US-7842837-B2 | Process for the synthesis of C-2, C-3 substituted N-alkylated indoles useful as cPLA2 inhibitors | WYETH LLC (US) | 2010-11-30 | — | — | US | disclosed |
| US-20090306428-A1 | Process for the Synthesis of C-2, C-3 Substituted N-Alkylated Indoles Useful as cPLA2 Inhibitors | WYETH LLC | 2009-12-10 | — | — | US | disclosed |
| US-20090306428-A1 | Process for the Synthesis of C-2, C-3 Substituted N-Alkylated Indoles Useful as cPLA2 Inhibitors | WYETH LLC | 2009-12-10 | — | — | US | disclosed |
| US-20090306428-A1 | Process for the Synthesis of C-2, C-3 Substituted N-Alkylated Indoles Useful as cPLA2 Inhibitors | WYETH LLC | 2009-12-10 | — | — | US | disclosed |
| US-7582772-B2 | Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as CPLA2 inhibitors | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-7582772-B2 | Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as CPLA2 inhibitors | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-7582772-B2 | Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as CPLA2 inhibitors | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| EP-1778629-A1 | PROCESS FOR THE SYNTHESIS C-2, C-3 SUBSTITUTED N-ALKYLATED INDOLES USEFUL AS CPLA2 INHIBITORS | Wyeth (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006023611-A1 | PROCESS FOR THE SYNTHESIS C-2, C-3 SUBSTITUTED N-ALKYLATED INDOLES USEFUL AS CPLA2 INHIBITORS | WYETH (US) | 2006-03-02 | — | — | WO | disclosed |
| US-20060041005-A1 | Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as CPLA2 inhibitors | WYETH (US) | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060041005-A1 | Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as CPLA2 inhibitors | PLA2G4A, PLA2R1, PLA2G12A | CA2 445/4885CA9 2392/4885ALDH1A1 1763/4885 |
| US-20110054189-A1 | Process For The Synthesis C-2, C-3 Substituted N-Alkylated Indoles Useful As CPLA2 Inhibitors | PLA2G4A, PLA2G4B, PLA2G1B | CA2 325/4885CA9 2227/4885ALDH1A1 2632/4885 |
| US-20090306428-A1 | Process for the Synthesis of C-2, C-3 Substituted N-Alkylated Indoles Useful as cPLA2 Inhibitors | PLA2G4A, PLA2G12A, PLA2R1 | CA2 416/4885CA9 2561/4885ALDH1A1 1722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.