Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | CLPP | Q16740 | 5/20 | 0.57 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22064969 | 0.88 | CYP3A4 (0.53) | CYP3A4SMN1; SMN2HIF1ACLPPGPR132 | |
| SCHEMBL13559495 | 0.80 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2HIF1ACLPPGPR132 | |
| SCHEMBL30085760 | 0.80 | CYP3A4 (1.00) | CYP3A4SMN1; SMN2HIF1ACLPPGPR132 | |
| SCHEMBL28722238 | 0.76 | CLPP (0.57) | CYP3A4SMN1; SMN2HIF1ACLPPGPR132 | |
| SCHEMBL18254991 | 0.76 | CLPP (0.89) | CYP3A4SMN1; SMN2HIF1ACLPPGPR132 | |
| SCHEMBL26265231 | 0.74 | CLPP (0.70) | CYP3A4SMN1; SMN2HIF1ACLPPGPR132 | |
| SCHEMBL26265229 | 0.73 | CLPP (0.73) | CYP3A4SMN1; SMN2HIF1ACLPPGPR132 | |
| SCHEMBL11802291 | 0.73 | CYP3A4 (0.53) | CYP3A4SMN1; SMN2HIF1ACLPPGPR132 | |
| Dordaviprone SCHEMBL29359574 | 0.73 | CLPP (1.00) | CYP3A4SMN1; SMN2HIF1ACLPPGPR132 | |
| Dordaviprone SCHEMBL16227974 | 0.73 | CLPP (1.00) | CYP3A4SMN1; SMN2HIF1ACLPPGPR132 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12630550-B2 | Pharmacophore for trail induction | THE SCRIPPS RESEARCH INSTITUTE (US) | 2026-05-19 | — | — | US | disclosed |
| EP-4470617-A2 | PHARMACOPHORE FOR TRAIL INDUCTION | The Scripps Research Institute (US) | 2024-12-04 | — | — | EP | disclosed |
| EP-3662910-B1 | PHARMACOPHORE FOR TRAIL INDUCTION | SCRIPPS RESEARCH INST (US) | 2024-09-18 | — | — | EP | disclosed |
| US-20240190877-A1 | PHARMACOPHORE FOR TRAIL INDUCTION | THE SCRIPPS RESEARCH INSTITUTE | 2024-06-13 | — | — | US | disclosed |
| US-11891392-B2 | Pharmacophore for trail induction | THE SCRIPPS RESEARCH INSTITUTE (US) | 2024-02-06 | — | — | US | disclosed |
| CN-111499636-B | Pharmacophores for TRAIL induction | 斯克里普斯研究学院（US） | 2023-01-13 | — | — | CN | disclosed |
| US-20220002300-A1 | PHARMACOPHORE FOR TRAIL INDUCTION | THE SCRIPPS RESEARCH INSTITUTE | 2022-01-06 | — | — | US | disclosed |
| US-20220002300-A1 | PHARMACOPHORE FOR TRAIL INDUCTION | THE SCRIPPS RESEARCH INSTITUTE | 2022-01-06 | — | — | US | disclosed |
| US-20200283440-A1 | PHARMACOPHORE FOR TRAIL INDUCTION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-09-10 | — | — | US | disclosed |
| US-20200283440-A1 | PHARMACOPHORE FOR TRAIL INDUCTION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-09-10 | — | — | US | disclosed |
| US-10633385-B2 | Pharmacophore for trail induction | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-04-28 | — | — | US | disclosed |
| CN-106456643-B | Pharmacophores for TRAIL induction | 斯克里普斯研究学院 | 2020-04-17 | — | — | CN | disclosed |
| US-20190284188-A1 | PHARMACOPHORE FOR TRAIL INDUCTION | THE SCRIPPS RESEARCH INSTITUTE | 2019-09-19 | — | — | US | disclosed |
| US-20190284188-A1 | PHARMACOPHORE FOR TRAIL INDUCTION | THE SCRIPPS RESEARCH INSTITUTE | 2019-09-19 | — | — | US | disclosed |
| US-10239877-B2 | Pharmacophore for trail induction | THE SCRIPPS RESEARCH INSTITUTE (US) | 2019-03-26 | — | — | US | disclosed |
| US-10239877-B2 | Pharmacophore for trail induction | THE SCRIPPS RESEARCH INSTITUTE (US) | 2019-03-26 | — | — | US | disclosed |
| US-20170107221-A1 | PHARMACOPHORE FOR TRAIL INDUCTION | THE SCRIPPS RESEARCH INSTITUTE | 2017-04-20 | — | — | US | disclosed |
| US-20170107221-A1 | PHARMACOPHORE FOR TRAIL INDUCTION | THE SCRIPPS RESEARCH INSTITUTE | 2017-04-20 | — | — | US | disclosed |
| US-20170107221-A1 | PHARMACOPHORE FOR TRAIL INDUCTION | THE SCRIPPS RESEARCH INSTITUTE | 2017-04-20 | — | — | US | disclosed |
| WO-2015153468-A1 | PHARMACOPHORE FOR TRAIL INDUCTION | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12630550-B2 | Pharmacophore for trail induction | STAT3, STAT1, STAT4 | CYP3A4 218/4885SMN1; SMN2 3993/4885HIF1A 3416/4885 |
| US-20190284188-A1 | PHARMACOPHORE FOR TRAIL INDUCTION | AIFM1, TNFRSF1A, TNFSF10 | CYP3A4 205/4885SMN1; SMN2 3880/4885HIF1A 2194/4885 |
| US-20220002300-A1 | PHARMACOPHORE FOR TRAIL INDUCTION | AIFM1, TNFRSF1A, TNFSF10 | CYP3A4 205/4885SMN1; SMN2 3880/4885HIF1A 2194/4885 |
| US-10633385-B2 | Pharmacophore for trail induction | AIFM1, TNFRSF1A, TNFSF10 | CYP3A4 205/4885SMN1; SMN2 3880/4885HIF1A 2194/4885 |
| US-20170107221-A1 | PHARMACOPHORE FOR TRAIL INDUCTION | TNFRSF1A, TNFSF11, TNFRSF9 | CYP3A4 171/4885SMN1; SMN2 4272/4885HIF1A 2241/4885 |
| US-10239877-B2 | Pharmacophore for trail induction | TNFRSF1A, TNFSF11, TNFRSF9 | CYP3A4 171/4885SMN1; SMN2 4272/4885HIF1A 2241/4885 |
| US-11891392-B2 | Pharmacophore for trail induction | AIFM1, TNFRSF1A, TNFSF10 | CYP3A4 205/4885SMN1; SMN2 3880/4885HIF1A 2194/4885 |
| US-20240190877-A1 | PHARMACOPHORE FOR TRAIL INDUCTION | AIFM1, TNFRSF1A, TNFSF10 | CYP3A4 205/4885SMN1; SMN2 3880/4885HIF1A 2194/4885 |
| US-20200283440-A1 | PHARMACOPHORE FOR TRAIL INDUCTION | AIFM1, TNFRSF1A, TNFSF10 | CYP3A4 205/4885SMN1; SMN2 3880/4885HIF1A 2194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.