SCHEMBL17148444

SCHEMBL17148444

Cc1ccc(CC(=O)Nc2nc3ccc(NC(=O)c4cscn4)cc3s2)cc1C(F)(F)F

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CSNK1D P48730 13/20 0.50
HSD17B10 Q99714 1/20 0.47
SMN1; SMN2 Q16637 3/20 0.46
LMNA P02545 2/20 0.46
MAPK1 P28482 2/20 0.46
KMT2A Q03164 2/20 0.46
HPGD P15428 1/20 0.46
ALOX15 P16050 1/20 0.46
WNT3A P56704 2/20 0.46
KDM4E B2RXH2 1/20 0.45
MEN1 O00255 1/20 0.45
MAPT P10636 1/20 0.45
RAB9A P51151 2/20 0.44
NPC1 O15118 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15701036 0.90 CSNK1D (0.52) CSNK1DLMNAKMT2AMEN1MAPT
SCHEMBL15701111 0.85 CSNK1D (0.69) CSNK1D
SCHEMBL15701138 0.84 WNT3A (0.58) CSNK1DSMN1; SMN2LMNAMAPK1KMT2A
SCHEMBL15701153 0.84 CSNK1D (0.61) CSNK1DHSD17B10SMN1; SMN2LMNAMAPK1
SCHEMBL15701151 0.82 CSNK1D (0.57) CSNK1DHSD17B10SMN1; SMN2LMNAMAPK1
SCHEMBL15701013 0.82 CSNK1D (0.66) CSNK1DKMT2AMEN1MAPT
SCHEMBL15701287 0.79 LMNA (0.65) CSNK1DSMN1; SMN2LMNAMAPK1KMT2A
SCHEMBL15701115 0.79 MAPT (0.51) CSNK1DSMN1; SMN2HPGDKDM4EMAPT
SCHEMBL15701230 0.78 DYRK2 (0.50) CSNK1DHPGDWNT3AKDM4EMAPT
SCHEMBL15701035 0.75 CSNK1D (0.50) CSNK1DLMNAMAPK1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2914592-B1 INHIBITORS OF CYTOMEGALOVIRUS BOEHRINGER INGELHEIM INT (DE) 2017-10-11 EP disclosed
US-9334249-B2 Inhibitors of cytomegalovirus BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2016-05-10 US disclosed
US-20150284348-A1 INHIBITORS OF CYTOMEGALOVIRUS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2015-10-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150284348-A1 INHIBITORS OF CYTOMEGALOVIRUS CDKN1A, CCNA1, IFNAR1 CSNK1D 247/4885HSD17B10 4010/4885SMN1; SMN2 4036/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.