Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LPL | P06858 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15205399 | 0.89 | CYP11B1 (0.52) | CYP11B1CYP11B2SMN1; SMN2HTTLMNA | |
| SCHEMBL17136919 | 0.86 | QPCT (0.50) | CYP11B1CYP11B2SMN1; SMN2HTTLMNA | |
| SCHEMBL14251023 | 0.82 | NPC1 (0.43) | SMN1; SMN2HTTLMNAALDH1A1KDM4E | |
| SCHEMBL3497335 | 0.81 | CYP11B1 (0.60) | CYP11B1CYP11B2SMN1; SMN2HTTLMNA | |
| SCHEMBL15333687 | 0.80 | CYP11B1 (0.52) | CYP11B1CYP11B2SMN1; SMN2HTTLMNA | |
| SCHEMBL29520169 | 0.79 | MAPT (0.40) | SMN1; SMN2LMNAKDM4ENPC1MAPT | |
| SCHEMBL17149327 | 0.79 | FGFR1 (0.51) | SMN1; SMN2HTTLMNAALDH1A1KDM4E | |
| SCHEMBL13559830 | 0.79 | CYP11B1 (0.71) | CYP11B1CYP11B2SMN1; SMN2HTTLMNA | |
| SCHEMBL15205440 | 0.79 | CDK9 (0.40) | CYP11B1CYP11B2SMN1; SMN2HTTLMNA | |
| SCHEMBL25431036 | 0.78 | FFAR1 (0.38) | SMN1; SMN2KDM4ENPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11834447-B2 | Indole derivatives and use thereof | PURDUE PHARMA L.P. (US) | 2023-12-05 | — | — | US | disclosed |
| US-20150284383-A1 | INDOLE DERIVATIVES AND USE THEREOF | PURDUE PHARMA L.P. | 2015-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11834447-B2 | Indole derivatives and use thereof | TRPC4, TRPV4, TRPV1 | CYP11B1 1428/4885CYP11B2 1514/4885SMN1; SMN2 780/4885 |
| US-20150284383-A1 | INDOLE DERIVATIVES AND USE THEREOF | TRPC4, TRPV4, TRPV1 | CYP11B1 1428/4885CYP11B2 1514/4885SMN1; SMN2 780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.