Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LPL | P06858 | 3/20 | 0.35 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29520593 | 0.90 | MTNR1A (0.39) | IRAK4TDP1LPLLIPGF11 | |
| SCHEMBL23638475 | 0.90 | MTNR1A (0.39) | IRAK4TDP1LPLLIPGF11 | |
| SCHEMBL14250361 | 0.86 | LMNA (0.50) | MAPTHSD17B10HDAC1TDP1LPL | |
| SCHEMBL14251023 | 0.85 | NPC1 (0.43) | MAPTHSD17B10IRAK4HDAC1TDP1 | |
| SCHEMBL17678212 | 0.85 | HDAC1 (0.39) | MAPTHSD17B10IRAK4HDAC1TDP1 | |
| SCHEMBL17042215 | 0.85 | MEN1 (0.51) | MAPTHSD17B10IRAK4TDP1LPL | |
| SCHEMBL15205670 | 0.84 | KDM4E (0.39) | MAPTHSD17B10IRAK4TDP1LPL | |
| SCHEMBL2144580 | 0.83 | MTNR1A (0.42) | MAPTIRAK4HDAC1NPC1RAB9A | |
| SCHEMBL17678096 | 0.83 | HDAC1 (0.45) | MAPTHSD17B10IRAK4HDAC1TDP1 | |
| SCHEMBL17678244 | 0.83 | MAPT (0.42) | MAPTHSD17B10IRAK4HDAC1LPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |