Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL17144818 | 0.98 | NOTUM (0.60) | NOTUMALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL18350038 | 0.88 | NOTUM (0.55) | NOTUMALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL19798382 | 0.86 | ALDH1A1 (0.61) | NOTUMALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL17149743 | 0.84 | POLB (0.63) | NOTUMLMNARAB9ASMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL17142044 | 0.83 | POLB (0.61) | NOTUMLMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8235977 | 0.77 | ALDH1A1 (0.67) | NOTUMALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL4652480 | 0.77 | NOTUM (1.00) | NOTUMALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL6404017 | 0.77 | ALDH1A1 (0.57) | NOTUMALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL6404013 | 0.77 | ALDH1A1 (0.57) | NOTUMALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL19343385 | 0.76 | RAB9A (0.81) | NOTUMALDH1A1LMNARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015150440-A1 | PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-10-08 | — | — | WO | disclosed |