Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405140 | 0.88 | ALDH1A1 (0.51) | ALDH1A1NOTUMLMNARAB9ASMN1; SMN2 | |
| SCHEMBL6602485 | 0.84 | TSHR (0.63) | LMNARAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL6605684 | 0.81 | NPC1 (0.47) | ALDH1A1NOTUMRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9961014 | 0.79 | NOTUM (0.61) | ALDH1A1NOTUMLMNARAB9ASMN1; SMN2 | |
| SCHEMBL19798382 | 0.79 | ALDH1A1 (0.61) | ALDH1A1NOTUMLMNARAB9ASMN1; SMN2 | |
| SCHEMBL6408205 | 0.79 | ALDH1A1 (0.56) | ALDH1A1NOTUMLMNARAB9ASMN1; SMN2 | |
| SCHEMBL8235977 | 0.77 | ALDH1A1 (0.67) | ALDH1A1NOTUMLMNARAB9ASMN1; SMN2 | |
| SCHEMBL17153204 | 0.77 | NOTUM (0.62) | ALDH1A1NOTUMLMNARAB9ASMN1; SMN2 | |
| SCHEMBL6404017 | 0.77 | ALDH1A1 (0.57) | ALDH1A1NOTUMLMNARAB9ASMN1; SMN2 | |
| SCHEMBL19343385 | 0.76 | RAB9A (0.81) | ALDH1A1NOTUMLMNARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107616-A1 | Alpha-ketoamide derivatives as cathepsin k inhibitors | SMITHKLINE BEECHAM CORPORATION | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107616-A1 | Alpha-ketoamide derivatives as cathepsin k inhibitors | CTSK, CTSE, CTSZ | ALDH1A1 2900/4885NOTUM 1001/4885LMNA 736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.