Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70414 | 0.89 | KDM1A (0.53) | GPR119KDM1APDE4DPDE4APDE4B | |
| SCHEMBL1654395 | 0.88 | KDM1A (0.50) | GPR119KDM1APDE4DPDE4APDE4B | |
| SCHEMBL213097 | 0.87 | KDM1A (0.56) | GPR119KDM1APDE4DPDE4APDE4B | |
| SCHEMBL6113016 | 0.85 | GPR119 (0.54) | GPR119KDM1APDE4DPDE4APDE4B | |
| SCHEMBL17155013 | 0.85 | CYP2D6 (0.39) | GPR119KDM1AALDH1A1LMNAMAPT | |
| SCHEMBL29175929 | 0.85 | GPR119 (0.52) | GPR119KDM1APDE4DPDE4APDE4B | |
| SCHEMBL3799984 | 0.83 | USP30 (0.48) | GPR119KDM1APDE4BALDH1A1LMNA | |
| SCHEMBL22265805 | 0.82 | KDM1A (0.55) | GPR119KDM1APDE4DPDE4APDE4B | |
| SCHEMBL29079727 | 0.82 | GPR119 (0.55) | GPR119KDM1APDE4DPDE4APDE4B | |
| SCHEMBL6493523 | 0.82 | KDM1A (0.46) | GPR119KDM1APDE4BALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015150557-A1 | MACROCYLIC PYRIDINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2015-10-08 | — | — | WO | disclosed |