Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3519431 | 0.68 | — | — | |
| SCHEMBL21847658 | 0.68 | PDK1 (0.37) | LRRK2 | |
| SCHEMBL31251646 | 0.65 | BRPF1 (0.42) | CCNA2CDK2CCNA1 | |
| SCHEMBL17156220 | 0.65 | NTRK1 (0.39) | — | |
| SCHEMBL28825939 | 0.64 | — | — | |
| SCHEMBL759910 | 0.63 | LRRK2 (0.40) | LRRK2CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL16934723 | 0.62 | IRAK4 (0.33) | — | |
| SCHEMBL21796786 | 0.62 | LRRK2 (0.33) | LRRK2CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL25333474 | 0.61 | ADORA3 (0.31) | — | |
| SCHEMBL18985784 | 0.61 | LRRK2 (0.46) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2929883-A1 | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors | INSTITUT PASTEUR (FR) | 2015-10-14 | — | — | EP | disclosed |