Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17156185 | 0.83 | DHODH (0.58) | DHODHRAB9ANPC1ALKBH1NR3C1 | |
| SCHEMBL17156135 | 0.83 | DHODH (0.74) | DHODHRAB9ANPC1ALKBH1NR3C1 | |
| SCHEMBL17156326 | 0.82 | DHODH (0.57) | DHODHRAB9ANPC1ALKBH1NR3C1 | |
| SCHEMBL17156091 | 0.81 | DHODH (0.61) | DHODHRAB9ANPC1ALKBH1NR3C1 | |
| SCHEMBL17156340 | 0.80 | DHODH (0.62) | DHODHRAB9ANPC1ALKBH1NR3C1 | |
| SCHEMBL13495147 | 0.76 | NPC1 (0.67) | RAB9ANPC1ALDH1A1LMNAMAPT | |
| SCHEMBL17156336 | 0.74 | DHODH (0.52) | DHODHRAB9ANPC1ALKBH1NR3C1 | |
| SCHEMBL17156256 | 0.73 | RAB9A (0.44) | RAB9ANPC1ALDH1A1LMNAMAPT | |
| SCHEMBL17156198 | 0.71 | DHODH (0.60) | DHODHRAB9ANPC1NR3C1ACACB | |
| SCHEMBL17156206 | 0.71 | DHODH (0.57) | DHODHNR3C1ACACBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2929883-A1 | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors | INSTITUT PASTEUR (FR) | 2015-10-14 | — | — | EP | disclosed |