Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17157651 | 1.00 | DAO (0.42) | DAOKMT2AMAPK1RAB9AMAPT | |
| SCHEMBL1775432 | 0.85 | KMT2A (0.56) | DAOKMT2AMAPK1RAB9AMAPT | |
| SCHEMBL1775435 | 0.85 | KMT2A (0.56) | DAOKMT2AMAPK1RAB9AMAPT | |
| SCHEMBL4486601 | 0.81 | GLA (0.44) | DAOKMT2AMAPK1RAB9AMAPT | |
| SCHEMBL4486603 | 0.81 | GLA (0.44) | DAOKMT2AMAPK1RAB9AMAPT | |
| SCHEMBL17158027 | 0.80 | RAB9A (0.39) | DAOKMT2AMAPK1RAB9AMAPT | |
| SCHEMBL17158028 | 0.80 | RAB9A (0.39) | DAOKMT2AMAPK1RAB9AMAPT | |
| SCHEMBL28774607 | 0.79 | CES2 (0.41) | DAOKMT2AMAPK1RAB9AMAPT | |
| SCHEMBL4607453 | 0.78 | MAOA (0.46) | DAOKMT2AMAPK1RAB9AMAPT | |
| SCHEMBL4607447 | 0.78 | MAOA (0.46) | DAOKMT2AMAPK1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376420-B2 | 4,5-dihydro-1H-pyrazole derivative or salts thereof, and pharmaceutical composition comprising same | YUHAN CORPORATION (KR) | 2016-06-28 | — | — | US | disclosed |
| US-20150291563-A1 | 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVE OR SALTS THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | YUHAN CORPORATION (KR) | 2015-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291563-A1 | 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVE OR SALTS THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | NR1H3, NR1H2, NR1H4 | DAO 4244/4885KMT2A 2576/4885MAPK1 1222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.