Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PKLR | P30613 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21049714 | 0.86 | TSHR (0.43) | TSHRPKMPKLRRORCHTR6 | |
| SCHEMBL17161027 | 0.83 | TSHR (0.45) | TSHRPKMPKLRRORCL3MBTL1 | |
| SCHEMBL17161033 | 0.82 | TSHR (0.40) | TSHRPKMPKLRCACNA1BRORC | |
| SCHEMBL21089378 | 0.82 | RORC (0.42) | TSHRPKMPKLRRORCGAA | |
| SCHEMBL17160978 | 0.82 | TSHR (0.40) | TSHRPKMPKLRCACNA1BRORC | |
| SCHEMBL17161059 | 0.82 | RORC (0.42) | TSHRPKMPKLRRORCGAA | |
| SCHEMBL28133662 | 0.81 | MMP2 (0.43) | TSHRPKMPKLRRORCHPGD | |
| SCHEMBL17158608 | 0.80 | TSHR (0.38) | TSHRPKMPKLRRORCGAA | |
| SCHEMBL17177767 | 0.80 | ALDH1A1 (0.41) | TSHRCACNA1BRORCKMT2AL3MBTL1 | |
| SCHEMBL17177790 | 0.80 | TSHR (0.43) | TSHRPKMPKLRCACNA1BRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106458955-B | Aryl substituted heterocyclyl sulfones | 格吕伦塔尔有限公司 | 2019-07-19 | — | — | CN | claimed |
| EP-3470406-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2019-04-17 | — | — | EP | claimed |
| US-9896440-B2 | Aryl substituted heterocyclyl sulfones | Grünenthal GmbH (DE) | 2018-02-20 | — | — | US | claimed |
| US-20150291573-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-15 | — | — | US | claimed |
| CN-106458955-B | Aryl substituted heterocyclyl sulfones | 格吕伦塔尔有限公司 | 2019-07-19 | — | — | CN | disclosed |
| EP-3470406-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2019-04-17 | — | — | EP | disclosed |
| EP-3470406-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2019-04-17 | — | — | EP | disclosed |
| US-9896440-B2 | Aryl substituted heterocyclyl sulfones | Grünenthal GmbH (DE) | 2018-02-20 | — | — | US | disclosed |
| US-9896440-B2 | Aryl substituted heterocyclyl sulfones | Grünenthal GmbH (DE) | 2018-02-20 | — | — | US | disclosed |
| EP-3131884-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2017-02-22 | — | — | EP | disclosed |
| CN-106458955-A | Aryl substituted heterocyclyl sulfones | 格吕伦塔尔有限公司 | 2017-02-22 | — | — | CN | disclosed |
| WO-2015158426-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-22 | — | — | WO | disclosed |
| WO-2015158426-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-22 | — | — | WO | disclosed |
| US-20150291573-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-15 | — | — | US | disclosed |
| US-20150291573-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-15 | — | — | US | disclosed |
| US-20150291573-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | Grünenthal GmbH (DE) | 2015-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291573-A1 | ARYL SUBSTITUTED HETEROCYCLYL SULFONES | TRPV1, CACNA1B, CACNA1C | TSHR 3297/4885PKM 2346/4885PKLR 2519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.