Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1715545 | 0.83 | TRPV1 (0.66) | TRPV1 | |
| SCHEMBL1715593 | 0.81 | MGLL (0.51) | MAPTKMT2AMEN1KDM4EGAA | |
| SCHEMBL1723394 | 0.81 | NPC1 (0.50) | MAPTKMT2ANPC1MEN1SMN1; SMN2 | |
| SCHEMBL12459925 | 0.79 | GAA (0.40) | MAPTKMT2AALDH1A1KDM4EGLA | |
| SCHEMBL1715876 | 0.77 | TRPV1 (0.52) | MAPTKMT2ANPC1MEN1SMN1; SMN2 | |
| SCHEMBL1716188 | 0.76 | CCR3 (0.37) | MAPTP2RY1TRPV1 | |
| SCHEMBL4341397 | 0.75 | TRPV1 (0.69) | MAPTKMT2ANPC1MEN1SMN1; SMN2 | |
| SCHEMBL13613656 | 0.70 | TRPV1 (0.62) | MAPTKMT2ANPC1MEN1RAB9A | |
| SCHEMBL1715687 | 0.66 | ADRA2C (0.42) | MAPTKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL10713102 | 0.66 | MEN1 (0.79) | MAPTKMT2ANPC1MEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685112-B1 | TETRAHYDRO-QUINOLINYLUREA DERIVATIVES AS VR1 ANTAGONISTS | BAYER SCHERING PHARMA AG (DE) | 2011-07-20 | — | — | EP | claimed |
| JP-2007523888-A | — | — | 2007-08-23 | — | — | JP | claimed |
| EP-1685112-A2 | TETRAHYDRO-QUINOLINYLUREA DERIVATIVES | Bayer HealthCare AG (DE) | 2006-08-02 | — | — | EP | claimed |
| WO-2005044802-A2 | TETRAHYDRO-QUINOLINYLUREA DERIVATIVES AS VRL ANTAGONISTS | BAYER HEALTHCARE AG (DE) | 2005-05-19 | — | — | WO | claimed |
| EP-1685112-B1 | TETRAHYDRO-QUINOLINYLUREA DERIVATIVES AS VR1 ANTAGONISTS | BAYER SCHERING PHARMA AG (DE) | 2011-07-20 | — | — | EP | disclosed |
| US-20100137361-A1 | Tetrahydro-Quinolinylurea Derivatives | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-03 | — | — | US | disclosed |
| US-7683076-B2 | Tetrahydro-quinolinylurea derivatives | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-03-23 | — | — | US | disclosed |
| EP-1685112-A2 | TETRAHYDRO-QUINOLINYLUREA DERIVATIVES | Bayer HealthCare AG (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005044802-A2 | TETRAHYDRO-QUINOLINYLUREA DERIVATIVES AS VRL ANTAGONISTS | BAYER HEALTHCARE AG (DE) | 2005-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137361-A1 | Tetrahydro-Quinolinylurea Derivatives | NMUR1, OPRL1, HVCN1 | MAPT 2668/4885KMT2A 4264/4885NPC1 2064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.