Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.89 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.89 |
| ▸ | CCR2 | P41597 | 7/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1716454 | 0.94 | ROCK2 (1.00) | ROCK2ROCK1CCR2 | |
| SCHEMBL1716648 | 0.94 | ROCK2 (0.79) | ROCK2ROCK1CCR2 | |
| SCHEMBL2804672 | 0.92 | ROCK2 (0.89) | ROCK2ROCK1CCR2 | |
| SCHEMBL1716471 | 0.92 | ROCK2 (0.89) | ROCK2ROCK1CCR2 | |
| SCHEMBL2801663 | 0.87 | ROCK2 (1.00) | ROCK2ROCK1CCR2 | |
| SCHEMBL661178 | 0.87 | ROCK2 (1.00) | ROCK2ROCK1CCR2 | |
| SCHEMBL661179 | 0.87 | ROCK2 (1.00) | ROCK2ROCK1CCR2 | |
| SCHEMBL1716567 | 0.86 | ROCK2 (0.79) | ROCK2ROCK1CCR2 | |
| SCHEMBL1716653 | 0.85 | ROCK2 (0.77) | ROCK2ROCK1CCR2 | |
| SCHEMBL1715804 | 0.85 | ROCK2 (0.89) | ROCK2ROCK1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1378247-B1 | VISUAL FUNCTION DISORDER IMPROVING AGENTS | SENJU PHARMA CO (JP) | 2016-08-24 | — | — | EP | disclosed |
| EP-2046339-B1 | RHO/ROCK/P13/AKT KINASE INHIBITORS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH PROTOZOAN PARASITES | UNIV PARIS CURIE (FR) | 2013-11-06 | — | — | EP | disclosed |
| EP-1256574-B1 | NITROGEN-CONTAINING COMPOUNDS HAVING KINASE INHIBITORY ACTIVITY AND DRUGS CONTAINING THE SAME | KYOWA HAKKO KIRIN CO LTD (JP) | 2012-01-18 | — | — | EP | disclosed |
| US-7696194-B2 | treating with fasudil hydrochloride; enzyme inhibitor of Rho kinase; promoting regeneration of an optic nerve cell | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2010-04-13 | — | — | US | disclosed |
| US-20090203678-A1 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PROTOZOAN PARASITIC DISEASES | UNIVERSITE PIERRE ET MARIE CURIE-PARIS VI (FR) | 2009-08-13 | — | — | US | disclosed |
| US-20090203678-A1 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PROTOZOAN PARASITIC DISEASES | UNIVERSITE PIERRE ET MARIE CURIE-PARIS VI (FR) | 2009-08-13 | — | — | US | disclosed |
| WO-2008015001-A1 | RHO/ROCK/P13/AKT KINASE INHIBITORS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH PROTOZOAN PARASITES | UNIVERSITE PIERRE ET MARIE CURIE-PARIS VI (FR) | 2008-02-07 | — | — | WO | disclosed |
| US-7217722-B2 | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2007-05-15 | — | — | US | disclosed |
| US-7217722-B2 | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2007-05-15 | — | — | US | disclosed |
| US-7217722-B2 | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2007-05-15 | — | — | US | disclosed |
| US-7109208-B2 | Visual function disorder improving agents | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2006-09-19 | — | — | US | disclosed |
| US-20060148852-A1 | Visual function disorder improving agents | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2006-07-06 | — | — | US | disclosed |
| US-20040106646-A1 | Visual function disorder improving agents | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2004-06-03 | — | — | US | disclosed |
| US-20040102437-A1 | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2004-05-27 | — | — | US | disclosed |
| EP-1378247-A1 | VISUAL FUNCTION IMPROVING AGENTS | Senju Pharmaceutical Co., Ltd. (JP) | 2004-01-07 | — | — | EP | disclosed |
| EP-1256574-A1 | NITROGEN-CONTAINING COMPOUNDS HAVING KINASE INHIBITORY ACTIVITY AND DRUGS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2002-11-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106646-A1 | Visual function disorder improving agents | ARHGDIA, GAP43, RHOT2 | ROCK2 41/4885ROCK1 25/4885CCR2 4252/4885 |
| US-20060148852-A1 | Visual function disorder improving agents | GAP43, ARHGDIA, RHOT2 | ROCK2 56/4885ROCK1 33/4885CCR2 4452/4885 |
| US-20090203678-A1 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF PROTOZOAN PARASITIC DISEASES | RHOA, ROCK1, ROCK2 | ROCK2 3/4885ROCK1 2/4885CCR2 3739/4885 |
| US-20040102437-A1 | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same | TNK2, ROCK1, ROCK2 | ROCK2 3/4885ROCK1 2/4885CCR2 3344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.