Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
| ▸ | GRN | P28799 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17166009 | 0.83 | GRN (0.35) | MAPK14MAPK13MAPK12MAPK11HRH3 | |
| SCHEMBL17166226 | 0.82 | UBE2T (0.41) | MAPK14MAPK13MAPK12MAPK11PTK2B | |
| SCHEMBL9906367 | 0.81 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11PTK2B | |
| SCHEMBL12789816 | 0.76 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11MEN1 | |
| SCHEMBL9909704 | 0.74 | PTK2B (0.41) | MAPK14MAPK13MAPK12MAPK11PTK2B | |
| SCHEMBL12789828 | 0.70 | ALDH1A1 (0.41) | MAPK14MAPK13MAPK12MAPK11GRN | |
| SCHEMBL9906366 | 0.69 | GRN (0.58) | MAPK14MAPK13MAPK12MAPK11GRN | |
| SCHEMBL9909705 | 0.69 | GRN (0.38) | MAPK14MAPK13MAPK12MAPK11GRN | |
| SCHEMBL9909706 | 0.68 | CDK8 (0.50) | MAPK14MAPK13MAPK12MAPK11GRN | |
| SCHEMBL10220768 | 0.68 | CA12 (0.42) | MEN1KMT2ACACNA1I |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9155737-B2 | Pyrido[2,3-B]pyrazin-8-substituted compounds and their use | INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE) (GB) | 2015-10-13 | — | — | US | disclosed |