Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17166225 | 0.83 | UBE2T (0.42) | UBE2TMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL17166010 | 0.82 | MAPK14 (0.38) | PTK2BMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL15887795 | 0.79 | MAPK14 (0.52) | MAPTPTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL9910330 | 0.71 | PTK2B (0.45) | PTK2BMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL14648636 | 0.71 | LMNA (0.63) | UBE2TSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL10220768 | 0.70 | CA12 (0.42) | MAPTLMNA | |
| SCHEMBL2269126 | 0.70 | ALDH1A1 (0.51) | MAPTSMN1; SMN2TDP1RECQLRAB9A | |
| SCHEMBL30309516 | 0.70 | ALDH1A1 (0.51) | MAPTSMN1; SMN2TDP1RECQLRAB9A | |
| SCHEMBL12335148 | 0.68 | NPC1 (0.42) | UBE2TMAPTMAPK14SMN1; SMN2TDP1 | |
| SCHEMBL15887794 | 0.68 | NR1I2 (0.45) | MAPTMAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9155737-B2 | Pyrido[2,3-B]pyrazin-8-substituted compounds and their use | INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE) (GB) | 2015-10-13 | — | — | US | disclosed |