Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16692508 | 0.86 | ADORA3 (0.41) | NPC1ALDH1A1HSD17B10RAB9AKDM4E | |
| SCHEMBL99394 | 0.82 | NPC1 (0.38) | NPC1ALDH1A1HSD17B10RAB9AKDM4E | |
| SCHEMBL18638503 | 0.80 | NPC1 (0.37) | NPC1ALDH1A1HSD17B10RAB9AKDM4E | |
| SCHEMBL99579 | 0.78 | PRKCI (0.53) | NPC1ALDH1A1HSD17B10RAB9AKDM4E | |
| SCHEMBL99395 | 0.75 | ALDH1A1 (0.39) | NPC1ALDH1A1HSD17B10RAB9AKDM4E | |
| SCHEMBL5221412 | 0.73 | MAPT (0.44) | NPC1ALDH1A1HSD17B10RAB9AKDM4E | |
| SCHEMBL22930879 | 0.73 | MET (0.43) | NPC1ALDH1A1HSD17B10RAB9AKDM4E | |
| SCHEMBL22930881 | 0.73 | ALDH1A1 (0.40) | NPC1ALDH1A1HSD17B10RAB9AKDM4E | |
| SCHEMBL18602392 | 0.73 | ADORA3 (0.44) | NPC1ALDH1A1HSD17B10RAB9AKDM4E | |
| SCHEMBL5215815 | 0.73 | GRM4 (0.54) | NPC1ALDH1A1HSD17B10RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2455382-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2012-05-23 | — | — | EP | disclosed |
| EP-2426129-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2012-03-07 | — | — | EP | disclosed |