Tryptophan

Tryptophan

SCHEMBL1716928

C[C@H](Nc1c[nH]c2ccccc12)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

nearest known ligand 0.74

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.74
MAPT P10636 3/20 0.74
KMT2A Q03164 3/20 0.74
LMNA P02545 2/20 0.74
TSHR P16473 2/20 0.74
BLM P54132 2/20 0.74
PMP22 Q01453 2/20 0.74
MEN1 O00255 2/20 0.74
MPO P05164 1/20 0.74
HIF1A Q16665 1/20 0.74
APAF1 O14727 1/20 0.60
POLB P06746 1/20 0.60
RECQL P46063 1/20 0.60
L3MBTL1 Q9Y468 1/20 0.60
HTR1A P08908 2/20 0.54
HTR2A P28223 2/20 0.54
HTR2C P28335 2/20 0.54
SLC6A4 P31645 2/20 0.54
HTR7 P34969 2/20 0.54
HTR2B P41595 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tryptophan SCHEMBL9819919 0.89 MAPT (0.68) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL5065247 0.86 KDM4E (0.89) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL5065251 0.86 KDM4E (0.89) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL27748750 0.86 KDM4E (0.94) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL27748748 0.86 KDM4E (0.94) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL28580277 0.86 KDM4E (0.94) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL18113708 0.86 KDM4E (0.64) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL23141133 0.86 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL4732052 0.86 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL475350 0.86 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1520073-B1 TRIAZINNYLAMINOSTILBENE DISULPHONIC ACID MIXTURES BASF SE (DE) 2012-01-18 EP claimed
EP-1520073-B1 TRIAZINNYLAMINOSTILBENE DISULPHONIC ACID MIXTURES BASF SE (DE) 2012-01-18 EP disclosed