Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.76 |
| ▸ | HPGD | P15428 | 5/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.76 |
| ▸ | POLB | P06746 | 2/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.72 |
| ▸ | CASP1 | P29466 | 2/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | THRB | P10828 | 2/20 | 0.68 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | MYC | P01106 | 1/20 | 0.61 |
| ▸ | MAX | P61244 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718546 | 0.92 | MAPT (0.72) | MAPTHPGDKDM4EPOLBTSHR | |
| SCHEMBL1718635 | 0.89 | ALDH1A1 (0.75) | MAPTHPGDKDM4EPOLBTSHR | |
| SCHEMBL1719017 | 0.88 | SMN1; SMN2 (0.74) | MAPTHPGDKDM4EPOLBTSHR | |
| SCHEMBL1718989 | 0.88 | MAPT (0.75) | MAPTHPGDKDM4EPOLBTSHR | |
| SCHEMBL1718145 | 0.86 | MAPT (0.77) | MAPTHPGDKDM4EPOLBTSHR | |
| SCHEMBL1718780 | 0.86 | MAPT (0.74) | MAPTHPGDKDM4EPOLBTSHR | |
| SCHEMBL1718904 | 0.86 | MYC (0.75) | MAPTHPGDKDM4EPOLBTSHR | |
| SCHEMBL1719150 | 0.85 | HPGD (0.63) | MAPTHPGDKDM4EPOLBTSHR | |
| SCHEMBL1719343 | 0.85 | ALDH1A1 (0.68) | MAPTHPGDKDM4EPOLBTSHR | |
| Benzylamine SCHEMBL1718987 | 0.85 | MAPT (0.82) | MAPTHPGDKDM4EPOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |