Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.43 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17177244 | 0.92 | GRM5 (0.49) | GRM5HSD11B1ALDH1A1TSHRHPGD | |
| SCHEMBL17809474 | 0.90 | ALDH1A1 (0.57) | GRM5HSD11B1ALDH1A1TSHRHPGD | |
| SCHEMBL25810399 | 0.86 | ALDH1A1 (0.63) | GRM5HSD11B1ALDH1A1TSHRHPGD | |
| SCHEMBL25840964 | 0.85 | ALDH1A1 (0.67) | GRM5HSD11B1ALDH1A1TSHRHPGD | |
| SCHEMBL25810400 | 0.82 | HSD11B1 (0.66) | GRM5HSD11B1ALDH1A1TSHRHPGD | |
| SCHEMBL25810394 | 0.82 | HPGD (0.56) | GRM5HSD11B1ALDH1A1TSHRHPGD | |
| SCHEMBL17173065 | 0.81 | GRM5 (0.51) | GRM5HSD11B1ALDH1A1TSHRHPGD | |
| SCHEMBL17173068 | 0.81 | GRM5 (0.51) | GRM5HSD11B1ALDH1A1TSHRHPGD | |
| SCHEMBL26197364 | 0.81 | GRM5 (0.74) | GRM5HSD11B1ALDH1A1TSHRHPGD | |
| SCHEMBL25668250 | 0.80 | GRM5 (0.63) | GRM5HSD11B1ALDH1A1TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9260439-B2 | Dihydropyrrolopyrimidine derivatives | PFIZER INC. (US) | 2016-02-16 | — | — | US | disclosed |
| US-20150291604-A1 | DIHYDROPYRROLOPYRIMIDINE DERIVATIVES | PFIZER (US) | 2015-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291604-A1 | DIHYDROPYRROLOPYRIMIDINE DERIVATIVES | DPYD, TPD52L2, DTYMK | GRM5 3893/4885HSD11B1 4200/4885ALDH1A1 851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.