Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.74 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.43 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19158899 | 0.92 | GRM5 (0.62) | GRM5HRH3HSD11B1ALDH1A1TSHR | |
| SCHEMBL12683549 | 0.89 | GRM5 (0.69) | GRM5HRH3HSD11B1ALDH1A1TSHR | |
| SCHEMBL22394198 | 0.87 | GRM5 (0.63) | GRM5HRH3HSD11B1ALDH1A1TSHR | |
| SCHEMBL17438776 | 0.83 | OPRM1 (0.66) | GRM5HRH3HSD11B1ALDH1A1TSHR | |
| SCHEMBL19158951 | 0.82 | GRM5 (0.53) | GRM5HRH3ALDH1A1TSHREPHX2 | |
| SCHEMBL24747258 | 0.81 | GRM5 (0.56) | GRM5HRH3HSD11B1ALDH1A1TSHR | |
| SCHEMBL17177147 | 0.81 | GRM5 (0.59) | GRM5HRH3HSD11B1ALDH1A1TSHR | |
| SCHEMBL18713241 | 0.80 | GRM5 (0.58) | GRM5HRH3HSD11B1ALDH1A1TSHR | |
| SCHEMBL17439133 | 0.79 | OPRL1 (0.71) | GRM5HRH3HSD11B1OPRM1OPRL1 | |
| SCHEMBL26131005 | 0.79 | GRM5 (0.53) | GRM5HRH3HSD11B1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230271973-A1 | BICYCLIC-HETEROCYCLE DERIVATIVES AND THEIR USES AS OREXIN-2 RECEPTOR AGONISTS | CENTESSA PHARMACEUTICALS (OREXIA) LIMITED (GB) | 2023-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230271973-A1 | BICYCLIC-HETEROCYCLE DERIVATIVES AND THEIR USES AS OREXIN-2 RECEPTOR AGONISTS | HCRTR2, HCRTR1, CRHR2 | GRM5 317/4885HRH3 23/4885HSD11B1 539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.