Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718750 | 0.91 | MAPT (0.66) | THRBMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL1718532 | 0.89 | THRB (0.84) | THRBMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1719908 | 0.87 | MAPT (0.68) | THRBMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1718195 | 0.86 | MAPT (0.74) | THRBMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1718706 | 0.84 | MAPT (0.59) | THRBMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1717969 | 0.83 | TP53 (0.72) | THRBMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1718359 | 0.82 | ALDH1A1 (0.63) | THRBMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1718458 | 0.82 | THRB (0.83) | THRBMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL1718244 | 0.82 | THRB (0.66) | THRBMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL1718632 | 0.82 | THRB (0.75) | THRBMAPTKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |