Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | TP53 | P04637 | 4/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | MYC | P01106 | 1/20 | 0.56 |
| ▸ | MAX | P61244 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TTR | P02766 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718476 | 0.92 | MAPT (0.62) | ALDH1A1KDM4ETP53THRBHPGD | |
| SCHEMBL1718451 | 0.91 | HPGD (0.69) | ALDH1A1KDM4ETP53THRBHPGD | |
| SCHEMBL1718692 | 0.91 | HPGD (0.67) | ALDH1A1KDM4ETP53THRBHPGD | |
| SCHEMBL1718371 | 0.90 | HPGD (0.71) | ALDH1A1KDM4ETP53THRBHPGD | |
| SCHEMBL1719619 | 0.88 | THRB (0.54) | ALDH1A1KDM4ETP53THRBHPGD | |
| SCHEMBL1719908 | 0.86 | MAPT (0.68) | ALDH1A1KDM4ETP53THRBHPGD | |
| SCHEMBL1718189 | 0.82 | ALDH1A1 (0.59) | ALDH1A1KDM4ETP53HPGDHSD17B10 | |
| SCHEMBL1718105 | 0.82 | ALDH1A1 (0.59) | ALDH1A1KDM4ETP53HPGDHSD17B10 | |
| SCHEMBL1717957 | 0.82 | TTR (0.70) | ALDH1A1KDM4ETP53THRBHPGD | |
| SCHEMBL1718155 | 0.82 | THRB (0.69) | ALDH1A1KDM4ETP53THRBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |