Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.75 |
| ▸ | TP53 | P04637 | 4/20 | 0.72 |
| ▸ | THRB | P10828 | 4/20 | 0.69 |
| ▸ | HPGD | P15428 | 5/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | CASP1 | P29466 | 3/20 | 0.68 |
| ▸ | CASP7 | P55210 | 3/20 | 0.68 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718605 | 0.92 | MAPT (0.73) | MAPTTP53THRBHPGDHSD17B10 | |
| SCHEMBL1718362 | 0.90 | THRB (0.82) | MAPTTP53THRBHPGDHSD17B10 | |
| SCHEMBL1718157 | 0.89 | TP53 (0.81) | MAPTTP53THRBHPGDHSD17B10 | |
| SCHEMBL1718091 | 0.84 | TP53 (0.73) | MAPTTP53THRBHPGDHSD17B10 | |
| SCHEMBL1719103 | 0.84 | TP53 (0.70) | MAPTTP53THRBHPGDHSD17B10 | |
| SCHEMBL1719086 | 0.84 | TP53 (0.81) | MAPTTP53THRBHPGDHSD17B10 | |
| SCHEMBL1718506 | 0.84 | TP53 (0.74) | MAPTTP53THRBHPGDHSD17B10 | |
| SCHEMBL1719994 | 0.82 | MAPT (0.76) | MAPTTP53THRBHPGDHSD17B10 | |
| SCHEMBL1718569 | 0.82 | MAPT (0.72) | MAPTTP53THRBHPGDHSD17B10 | |
| SCHEMBL1720013 | 0.81 | MAPT (0.76) | MAPTTP53THRBHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |