Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.82 |
| ▸ | MAPT | P10636 | 7/20 | 0.71 |
| ▸ | TP53 | P04637 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | HPGD | P15428 | 4/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | CASP1 | P29466 | 3/20 | 0.69 |
| ▸ | CASP7 | P55210 | 3/20 | 0.69 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718263 | 0.90 | MAPT (0.75) | THRBMAPTTP53ALDH1A1HPGD | |
| SCHEMBL1719697 | 0.90 | THRB (0.77) | THRBMAPTTP53ALDH1A1HPGD | |
| SCHEMBL1718532 | 0.89 | THRB (0.84) | THRBMAPTTP53ALDH1A1HPGD | |
| SCHEMBL1718458 | 0.88 | THRB (0.83) | THRBMAPTTP53ALDH1A1HPGD | |
| SCHEMBL1719991 | 0.88 | THRB (0.82) | THRBMAPTTP53ALDH1A1HPGD | |
| SCHEMBL1718506 | 0.88 | TP53 (0.74) | THRBMAPTTP53ALDH1A1HPGD | |
| SCHEMBL1718091 | 0.87 | TP53 (0.73) | THRBMAPTTP53ALDH1A1HPGD | |
| SCHEMBL1720222 | 0.85 | THRB (0.77) | THRBMAPTTP53ALDH1A1HPGD | |
| SCHEMBL1719086 | 0.85 | TP53 (0.81) | THRBMAPTTP53ALDH1A1HPGD | |
| SCHEMBL1718157 | 0.85 | TP53 (0.81) | THRBMAPTTP53ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |