Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28342817 | 0.87 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2LMNAMAPTSRC | |
| SCHEMBL29955556 | 0.84 | MAOB (0.39) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL7817452 | 0.81 | ALDH1A1 (0.63) | ALDH1A1LMNAMAPTL3MBTL1KDM4E | |
| SCHEMBL30457873 | 0.81 | PTGDR2 (0.44) | ALDH1A1SMN1; SMN2LMNAHPGDHTT | |
| SCHEMBL21639308 | 0.81 | PTGDR2 (0.44) | ALDH1A1SMN1; SMN2LMNAHPGDHTT | |
| SCHEMBL11865885 | 0.80 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2HPGDHTTL3MBTL1 | |
| SCHEMBL1748693 | 0.80 | LMNA (0.51) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL28120408 | 0.79 | LMNA (0.43) | ALDH1A1SMN1; SMN2LMNAMAPTHPGD | |
| SCHEMBL8709785 | 0.77 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2LMNAMAPTNPSR1 | |
| SCHEMBL17182684 | 0.76 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2LMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110642818-B | Method for preparing benzofuran-2-carboxamide compound | 云南师范大学 | 2023-05-30 | — | — | CN | claimed |
| CN-110642818-A | Method for preparing benzofuran-2-formamide compound | 云南师范大学 | 2020-01-03 | — | — | CN | claimed |
| CN-110642818-B | Method for preparing benzofuran-2-carboxamide compound | 云南师范大学 | 2023-05-30 | — | — | CN | disclosed |
| EP-3131893-B1 | POLYCYCLIC HERG ACTIVATORS | NOVARTIS AG (CH) | 2020-02-12 | — | — | EP | disclosed |
| EP-3131893-B1 | POLYCYCLIC HERG ACTIVATORS | NOVARTIS AG (CH) | 2020-02-12 | — | — | EP | disclosed |
| CN-110642818-A | Method for preparing benzofuran-2-formamide compound | 云南师范大学 | 2020-01-03 | — | — | CN | disclosed |
| EP-3131893-A1 | POLYCYCLIC HERG ACTIVATORS | Novartis AG (CH) | 2017-02-22 | — | — | EP | disclosed |
| US-20160108025-A1 | POLYCYCLIC HERG ACTIVATORS | NOVARTIS AG | 2016-04-21 | — | — | US | disclosed |
| US-20160108025-A1 | POLYCYCLIC HERG ACTIVATORS | NOVARTIS AG | 2016-04-21 | — | — | US | disclosed |
| US-20160108025-A1 | POLYCYCLIC HERG ACTIVATORS | NOVARTIS AG | 2016-04-21 | — | — | US | disclosed |
| US-9255093-B2 | Polycyclic HERG activators | NOVARTIS AG (CH) | 2016-02-09 | — | — | US | disclosed |
| US-9255093-B2 | Polycyclic HERG activators | NOVARTIS AG (CH) | 2016-02-09 | — | — | US | disclosed |
| US-20150299181-A1 | POLYCYCLIC HERG ACTIVATORS | NOVARTIS AG (CH) | 2015-10-22 | — | — | US | disclosed |
| US-20150299181-A1 | POLYCYCLIC HERG ACTIVATORS | NOVARTIS AG (CH) | 2015-10-22 | — | — | US | disclosed |
| US-20150299181-A1 | POLYCYCLIC HERG ACTIVATORS | NOVARTIS AG (CH) | 2015-10-22 | — | — | US | disclosed |
| WO-2015161052-A1 | POLYCYCLIC HERG ACTIVATORS | NOVARTIS AG (CH) | 2015-10-22 | — | — | WO | disclosed |
| WO-2015161052-A1 | POLYCYCLIC HERG ACTIVATORS | NOVARTIS AG (CH) | 2015-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160108025-A1 | POLYCYCLIC HERG ACTIVATORS | KCNH3, KCNH2, KCNJ11 | ALDH1A1 1847/4885SMN1; SMN2 3849/4885LMNA 1186/4885 |
| US-20150299181-A1 | POLYCYCLIC HERG ACTIVATORS | KCNH3, KCNH2, KCNJ11 | ALDH1A1 1847/4885SMN1; SMN2 3849/4885LMNA 1186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.