Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.81 |
| ▸ | POLB | P06746 | 3/20 | 0.81 |
| ▸ | RAB9A | P51151 | 2/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 8/20 | 0.62 |
| ▸ | CASP7 | P55210 | 5/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.62 |
| ▸ | CASP1 | P29466 | 4/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718968 | 0.90 | ALDH1A1 (1.00) | ALDH1A1KDM4EPOLBRAB9AKMT2A | |
| SCHEMBL1718955 | 0.87 | ALDH1A1 (0.81) | ALDH1A1KDM4EPOLBRAB9AKMT2A | |
| SCHEMBL1718891 | 0.85 | KDM4E (0.67) | ALDH1A1KDM4EPOLBRAB9AKMT2A | |
| SCHEMBL1719736 | 0.81 | KDM4E (0.59) | ALDH1A1KDM4EPOLBRAB9AKMT2A | |
| SCHEMBL1719735 | 0.80 | HPGD (0.81) | ALDH1A1KDM4EPOLBRAB9AKMT2A | |
| SCHEMBL25970334 | 0.79 | OPRK1 (0.66) | ALDH1A1KDM4EPOLBRAB9AKMT2A | |
| SCHEMBL1718294 | 0.79 | ALDH1A1 (0.80) | ALDH1A1KDM4EPOLBRAB9AKMT2A | |
| SCHEMBL1719216 | 0.78 | OPRK1 (0.64) | ALDH1A1KDM4EPOLBKMT2AHPGD | |
| Hydrochloric Acid SCHEMBL30516229 | 0.78 | OPRK1 (0.64) | ALDH1A1KDM4EPOLBRAB9AKMT2A | |
| SCHEMBL25970233 | 0.78 | OPRK1 (0.69) | ALDH1A1KDM4EPOLBRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |