Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.65 |
| ▸ | MAOB | P27338 | 9/20 | 0.60 |
| ▸ | MAOA | P21397 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 6/20 | 0.54 |
| ▸ | BRD2 | P25440 | 4/20 | 0.53 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.53 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19129744 | 0.92 | MAOB (0.58) | ABCB1MAOBMAOAKDM4EALDH1A1 | |
| SCHEMBL17185518 | 0.89 | ABCB1 (0.69) | ABCB1MAOBMAOAKDM4EALDH1A1 | |
| SCHEMBL20291074 | 0.86 | BRD4 (0.71) | ABCB1MAOBMAOAKDM4EALDH1A1 | |
| SCHEMBL17185540 | 0.83 | BRD4 (0.77) | ABCB1MAOBMAOAKDM4EALDH1A1 | |
| SCHEMBL17185522 | 0.82 | ABCB1 (0.72) | ABCB1MAOBMAOAKDM4EALDH1A1 | |
| SCHEMBL17185525 | 0.82 | BRD4 (0.78) | ABCB1MAOBMAOAKDM4EALDH1A1 | |
| SCHEMBL17185537 | 0.81 | ABCB1 (0.70) | ABCB1MAOBMAOAKDM4EALDH1A1 | |
| SCHEMBL19129435 | 0.81 | MAOB (0.61) | ABCB1MAOBMAOAKDM4EALDH1A1 | |
| SCHEMBL17193741 | 0.81 | MAOB (0.81) | ABCB1MAOBMAOAKDM4EALDH1A1 | |
| Trimethylapigenin SCHEMBL1421585 | 0.80 | ABCB1 (1.00) | ABCB1MAOBMAOAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170204078-A1 | APIGENIN ANALOGS, COMPOSITIONS, AND METHODS RELATED THERETO | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-07-20 | — | — | US | claimed |
| WO-2015161309-A1 | APIGENIN ANALOGS, COMPOSITIONS, AND METHODS RELATED THERETO | ZHOU JIA (US) | 2015-10-22 | — | — | WO | claimed |
| US-9868715-B2 | Apigenin analogs, compositions, and methods related thereto | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMS (US) | 2018-01-16 | — | — | US | disclosed |
| US-9868715-B2 | Apigenin analogs, compositions, and methods related thereto | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMS (US) | 2018-01-16 | — | — | US | disclosed |
| US-20170204078-A1 | APIGENIN ANALOGS, COMPOSITIONS, AND METHODS RELATED THERETO | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-07-20 | — | — | US | disclosed |
| US-20170204078-A1 | APIGENIN ANALOGS, COMPOSITIONS, AND METHODS RELATED THERETO | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-07-20 | — | — | US | disclosed |
| WO-2015161309-A1 | APIGENIN ANALOGS, COMPOSITIONS, AND METHODS RELATED THERETO | ZHOU JIA (US) | 2015-10-22 | — | — | WO | disclosed |
| WO-2015161309-A1 | APIGENIN ANALOGS, COMPOSITIONS, AND METHODS RELATED THERETO | ZHOU JIA (US) | 2015-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170204078-A1 | APIGENIN ANALOGS, COMPOSITIONS, AND METHODS RELATED THERETO | CBS, CTH, PTGIS | ABCB1 831/4885MAOB 1245/4885MAOA 1595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.