Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.57 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718992 | 0.95 | USP2 (0.69) | MAPK1USP2GAAMAPTL3MBTL1 | |
| SCHEMBL1719737 | 0.93 | GAA (0.61) | MAPK1USP2GAAMAPTL3MBTL1 | |
| SCHEMBL1718370 | 0.88 | USP2 (0.59) | MAPK1USP2GAAMAPTL3MBTL1 | |
| SCHEMBL1718567 | 0.87 | KMT2A (0.65) | MAPK1USP2GAAMAPTL3MBTL1 | |
| SCHEMBL1718836 | 0.87 | GAA (0.65) | MAPK1USP2GAAMAPTL3MBTL1 | |
| SCHEMBL1718697 | 0.82 | MAPK1 (0.69) | MAPK1USP2GAAMAPTL3MBTL1 | |
| SCHEMBL1718280 | 0.81 | MAPK1 (0.68) | MAPK1USP2GAAMAPTL3MBTL1 | |
| SCHEMBL4197430 | 0.81 | USP2 (1.00) | MAPK1USP2GAAMAPTALDH1A1 | |
| SCHEMBL1718638 | 0.80 | MAPK1 (0.66) | MAPK1USP2GAAMAPTL3MBTL1 | |
| SCHEMBL1718369 | 0.78 | RXFP1 (0.59) | MAPK1USP2GAAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | claimed |
| EP-1506196-B1 | PYRAZOLOPYRIMIDINES AS SODIUM CHANNEL INHIBITORS | ICAGEN INC (US) | 2012-01-18 | — | — | EP | disclosed |