Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.35 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.35 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5308535 | 0.77 | MAPT (0.43) | KMT2AMEN1KCNH3MAPTHTT | |
| SCHEMBL5999111 | 0.75 | MAPT (0.48) | KMT2AMEN1KCNH3MAPTHTT | |
| Hydrochloric Acid SCHEMBL2149444 | 0.73 | KCNH3 (0.50) | KMT2AMEN1KCNH3MAPTHTT | |
| SCHEMBL8613449 | 0.72 | KMT2A (0.42) | KMT2AMEN1MAPTHTTMAPK1 | |
| SCHEMBL8244931 | 0.71 | KCNH3 (0.57) | KMT2AKCNH3MAPTHTTMAPK1 | |
| SCHEMBL5335241 | 0.71 | KCNH3 (0.41) | KMT2AMEN1KCNH3MAPTHTT | |
| SCHEMBL23084860 | 0.71 | KDM4E (0.38) | KMT2AMEN1KCNH3MAPTHTT | |
| SCHEMBL1567049 | 0.70 | KCNH3 (0.65) | KMT2AKCNH3MAPTHTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL7393433 | 0.70 | KCNH3 (0.60) | KMT2AKCNH3MAPTHTTMAPK1 | |
| SCHEMBL2064760 | 0.70 | MAPT (0.57) | KMT2AMEN1KCNH3MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426108-A1 | Processes and intermediates for preparing fused heterocyclic kinase inhibitors | MethylGene Inc. (CA) | 2012-03-07 | — | — | EP | disclosed |