Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.41 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5335241 | 0.88 | KCNH3 (0.41) | MAPTSSTR3MEN1KMT2AMAPK1 | |
| SCHEMBL5309004 | 0.86 | KCNH3 (0.44) | MAPTMEN1KMT2AMAPK1NPC1 | |
| SCHEMBL21800004 | 0.81 | APP (0.44) | MAPTMEN1KMT2AHTTRAB9A | |
| SCHEMBL13167595 | 0.81 | HRH3 (0.49) | MAPTMEN1KMT2AMAPK1NPC1 | |
| SCHEMBL12932913 | 0.80 | ALDH1A1 (0.40) | MAPTRPS6KA2MEN1KMT2AMAPK1 | |
| SCHEMBL4762870 | 0.80 | MAPT (0.56) | MAPTMEN1KMT2AHTTRAB9A | |
| SCHEMBL5471155 | 0.78 | MAPT (0.38) | MAPTHTTGAAALDH1A1 | |
| SCHEMBL2064760 | 0.78 | MAPT (0.57) | MAPTRPS6KA2MEN1KMT2AGAA | |
| SCHEMBL24848921 | 0.78 | ALDH1A1 (0.43) | MAPTMEN1KMT2ANPC1HTT | |
| SCHEMBL171858 | 0.77 | KMT2A (0.38) | MAPTRPS6KA2MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038571-A2 | PROLYL HYDROXYLASE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |